1. Kartiranje habitatnih tipov in popis morske biodiverzitete na območju koprske občine : končno poročiloLovrenc Lipej, Ana Fortič, Leon Lojze Zamuda, Tihomir Makovec, Borut Mavrič, Valentina Pitacco, Milijan Šiško, Domen Trkov, Martina Orlando-Bonaca, Danijel Ivajnšič, 2022, final research report Keywords: morska biologija, biološke lastnosti, skupine vrst, habitatni tipi, morski ekosistemi, morska biodiverziteta, morska biološka raznovrstnost, Občina Koper, poročila
Published in DiRROS: 24.04.2024; Views: 6; Downloads: 0 |
2. The influence of cytokine gene polymorphisms on the risk of developing gastric cancer in patients with Helicobacter pylori infectionDavid Štubljar, Samo Jeverica, Tomislav Jukić, Miha Skvarč, Tadeja Pintar, Bojan Tepeš, Rajko Kavalar, Borut Štabuc, Alojz Ihan, 2015, original scientific article Keywords: cytokine gene, gastric cancer, Helicobacter pylori infection
Published in DiRROS: 16.04.2024; Views: 75; Downloads: 14
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3. Circulating serum sVCAM-1 concentration inadvanced ovarian cancer patients : correlation with concentration in ascitesMarina Jakimovska, Katarina Černe, Ivan Verdenik, Borut Kobal, 2014, original scientific article Abstract: Background. Vascular cell adhesion molecule-1 (VCAM-1) is associated with ovarian cancer progression but theorigin of its soluble form (sVCAM-1) in serum is not well investigated. The purpose of this study was to elucidate whetherthe concentration of sVCAM-1 in serum correlates with the concentration in ascites, that represents local tumour environment,and with systemic inflammation, various clinicopathological characteristics, and patient outcome.Patients and methods. Thirty-six patients with advanced ovarian cancer were included in the study. Serum forsVCAM-1 analysis was obtained prior to surgery. Ascites samples were collected at the beginning of the operation.Clinical data were collected from patients medical records. sVCAM-1 in samples was analysed by flow cytometricbead-based assay. The mean follow-up period was 11 months (range 0-23) from the time of surgery.Results. Serum sVCAM-1 concentrations are positively correlated to ascites sVCAM-1 concentrations. There was aweakly positive correlation of serum sVCAM-1 with tumour size and no correlation with inflammatory tumour markers,FIGO stage or grade. Higher concentrations of sVCAM-1 were associated with poor disease outcome (death fromovarian cancer) in almost all cases before chemotherapy was started.Conclusion. This is the first study demonstrating that serum concentrations of sVCAM-1 in advanced ovarian cancerpatients correlate with sVCAM-1 concentrations in ascites, thus expressing the biologic potential of malignant diseaseto metastasis, rather than systemic inflammation. Higher serum and ascites sVCAM-1 concentrations might have predictivepotential for different biologic behaviour.
Published in DiRROS: 16.04.2024; Views: 74; Downloads: 16
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4. Microsatellite instability in colorectal cancerMatej Horvat, Borut Štabuc, 2011, review article Abstract: Background. Colorectal cancer (CRC) is the third most common cancer in the world. In 75% CRC develops sporadically, in 25% hereditary or as a consequenceof inflammatory bowel disease. CRC carcinogenesis develops over many years. The cause of CRC in 85% is chromosomal instability (CIN) and in 15% microsatellite instability (MSI-H), where hereditary nonpolyposis colorectal cancer (HNPCC) represents 10-20%. Microsatellite sequences (MS) arerepeated sequences of short stretches of DNA all over the genome. Microsatellite stability (MSS) means MS are the same in each cell of an individual, whereas microsatellite instability (MSI-H) means MS differ in normal and cancer cells of an individual. The cause of MSI-H is a damaged mismatch repair mechanism (MMR), with the most important MMR proteins being MSH2, MLH1 and MSH6. Conclusions. MSI-H seems to be an important prognostic factor in CRC and an important predictive factor of CRC chemotherapeutic treatment efficacy. Clinical trials conducted until now have shown contradictory findings in different chemotherapeutic settings, adjuvant and palliative; therefore MSI-H is going to be the object of the future research. The future of cancer treatment is in the individualized therapy based on molecular characteristics of the tumour, such as MSI-H in CRC.
Published in DiRROS: 19.03.2024; Views: 115; Downloads: 52
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5. Increased late urinary toxicity with whole pelvic radiotherapy after prostatectomyBorut Kragelj, 2009, original scientific article Abstract: Background. Radiotherapy aimed at prostatic bed (PBRT) can prevent recurrence or reestablish remission in prostate cancer patients primarily treated with prostatectomy. In selected patients results may be improved with the additional irradiation of pelvic nodes (WPRT). Patients and methods. The objective of the study was to evaluate late toxicity of postoperative radiotherapy in 43 patients - 21/43 treated with WPRT. Dysuria, haematuria, nocturia, continence and obstructive urination problems as well as urgency, continence, frequency, pain and bleeding of defecations were prospectively registered and converted to a modified Radiation Therapy Oncology Group (RTOG)- late effects normal tissue (LENT) scoring system. Median tumour dose (TD) for PBRT was 64.8 (59.4-70.0) Gy and for WPRT 50.4 (48.0-56.0) Gy. Results. More important than the deterioration of intestinal function (worsening for 1 grade in 54% and >= 2 grades in 5% of patients) was the deterioration of urinary function (worsening for 1 grade in 33% and >= 2 grades in 26% of patients). This appeared to be more frequent in patients withWPRT than PBRT (67% vs. 50% of patients) especially in conjunction with WPRT TD > 52 Gy (deterioration in 71% of patients). Conclusions. Although several factors may influence increased urinary toxicity after WPRT, it seems reasonable to lower the urinary bladder dose as it possible with novel radiation techniques.
Published in DiRROS: 08.03.2024; Views: 108; Downloads: 24
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9. Small-bowel carcinoid presenting with acute bleeding detected upon wireless capsule endoscopyŽiva Mrevlje, Marko Sever, Borut Kocijančič, 2005, original scientific article Abstract: Background. Intestine carcinoid usually presents with clinical symptoms and signs deriving from its endocrinological influences and rarely bleeds profusely. Case report. We present a patient with intestinal bleeding of unknown origin. After conventional diagnostic procedures only wireless capsuleendosopy was able to discover a tumour of small bowel, which was the reason of bleeding. On patohistological examination after the surgical resection it proved to be a small bowel carcinoid. Conclusions. There are indications that WCE, besides being the first small bowel imaging technique, is a very important diagnostic tool, deserving consideration in the early phases of diagnosing small-bowel disease, especially in less intensive or occult bleeding.
Published in DiRROS: 14.02.2024; Views: 132; Downloads: 24
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10. Setup and its effect on safety margin in conformal radiotherapy of the prostateBorut Kragelj, 2005, original scientific article Abstract: Background. In radiotherapy, setup errors in positioning the patients influence the size of safety margin and thereby also the size of irradiation field and toxicity of radiotherapy. Methods. The setup errors were calculated by evaluating the deviations from the measured distance between the irradiation field margin and the bony pelvis. Results. The research was performed on 23 patients. With respect to lateral, craniocaudal and anteroposterior axis, the observed systemic error ranged from -5 to + 9 mm, -4to +5 mm, and from -4 to +4 mm, respectively, whereas the observed random error ranged from 0 to 7.5 mm, 0 to 3.6 mm, and from 0 to 4.2 mm, respectively. The safety margin, with the 90% probability to cover clinical target volume (CTV) and allowing for the prostate position variability, measured 9 mm, 9.5 mm, 7 mm, and 10 mm in the respective lateral, craniocaudal, anterior and dorsal direction. Conclusions. Irradiation of the prostate with a 7 mm dorsal safety margin, allowing for 90% coverage probability of CTV, was feasible in 22/23 patients on condition that the grosssystemic error (>3mm) was eliminated.
Published in DiRROS: 14.02.2024; Views: 136; Downloads: 30
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