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Towards designing new nano-scale protein architectures
Jana Aupič, Žiga Strmšek, Fabio Lapenta, Roman Jerala, 2016

DiRROS - Published: 12.11.2018; Views: 331; Downloads: 57
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Design principles for rapid folding of knotted DNA nanostructures
Roman Jerala, Jonathan P. K. Doye, Tomaž Pisanski, Nino Bašić, Helena Gradišar, Slavko Čeru, John S. Schreck, Vid Kočar, 2016

Abstract: Knots are some of the most remarkable topological features in nature. Self-assembly of knotted polymers without breaking or forming covalent bonds is challenging, as the chain needs to be threaded through previously formed loops in an exactly defined order. Here we describe principles to guide the folding of highly knotted single-chain DNA nanostructures as demonstrated on a nano-sized square pyramid. Folding of knots is encoded by the arrangement of modules of different stability based on derived topological and kinetic rules. Among DNA designs composed of the same modules and encoding the same topology, only the one with the folding pathway designed according to the "free-end" rule folds efficiently into the target structure. Besides high folding yield on slow annealing, this design also folds rapidly on temperature quenching and dilution from chemical denaturant. This strategy could be used to design folding of other knotted programmable polymers such as RNA or proteins.
DiRROS - Published: 13.04.2016; Views: 1983; Downloads: 36
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