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71.
72.
Diagnostične slikovne metode
2020

Ključne besede: novotvorbe dojke, zdravljenje, rak dojke, zborniki
DiRROS - Objavljeno: 06.04.2021; Ogledov: 11; Prenosov: 3
.pdf Celotno besedilo (13,70 MB)

73.
74.
Management of BRCA positive ovarian breast cancer : Ljubljana, 7. 4. 2016
Simona Borštnar, 2016

DiRROS - Objavljeno: 02.04.2021; Ogledov: 48; Prenosov: 9
.pdf Celotno besedilo (12,28 MB)

75.
Somatic mutations and the risk of undifferentiated autoinflammatory disease in MDS : an under-recognized but prognostically important complication
Abdulla Watad, Mark Kačar, Nicola Luigi Bragazzi, Qiao Zhou, Miriam Jassam, Jan Taylor, Eve Roman, Alexandra Smith, Richard A. Jones, Howard Amital, 2021

Povzetek: Objectives: We theorized that myelodysplastic syndrome (MDS) with somatic mutations and karyotype abnormalities are associated with autoinflammation, and that the presence of autoinflammatory disease affected prognosis in MDS. Methods: One hundred thirty-four MDS patients were assessed for the prevalence of autoinflammatory complications and its link with karyotypes and somaticmutation status. Autoinflammatory complications were described either as well-defined autoinflammatory diseases (AD) or undifferentiated "autoinflammatory disease" (UAD) (defined as CRP over 10.0 mg/L on five consecutive occasions, taken at separate times and not explained by infection). Several patient characteristics including demographic, clinical, laboratory, cytogenetics charts, and outcomes, were compared between different groups. Results: Sixty-two (46.3%) patients had an autoinflammatory complication manifesting as arthralgia (43.5% vs. 23.6%, p = 0.0146), arthritis (30.6% vs. 15.3%, p = 0.0340), skin rash (27.4% vs. 12.5%, p = 0.0301), pleuritis (14.5% vs. 4.2%, p = 0.0371) and unexplained fever (27.4% vs. 0%, p < 0.0001). AD were found in 7.4% of MDS patients (with polymyalgia rheumatic being the most frequently one). Classical autoimmune diseases were found only in 4 MDS patients (3.0%). Transcription factor pathway mutations (RUNX1, BCOR, WTI, TP53) (OR 2.20 [95%CI 1.02-4.75], p = 0.0451) and abnormal karyotypes (OR 2.76 [95%CI 1.22-6.26], p = 0.0153) were associated with autoinflammatory complications. Acute leukaemic transformation was more frequent in MDS patients with autoinflammatory features than those without (27.4% vs. 9.7%, p = 0.0080). Conclusions: Autoinflammatory complications are common inMDS. Somatic mutations of transcription factor pathways and abnormal karyotypes are associated with greater risk of autoinflammatory complications, which are themselves linked to malignant transformation and a worse prognosis.
Ključne besede: myelodysplastic syndromes - genetics, autoinflammation, undifferentiated autoinflammatory disease, molecular characterization, somatic mutations
DiRROS - Objavljeno: 31.03.2021; Ogledov: 39; Prenosov: 23
URL Celotno besedilo (0,00 KB)

76.
Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma : an international multicenter study
Luka Brčić, Thomas Klikovits, Zsolt Megyesfalvi, Berta Mosleh, Katharina Sinn, Richard Hritcu, Viktoria Laszlo, Tanja Čufer, Aleš Rozman, Izidor Kern, Katja Mohorčič, 2021

Povzetek: Background: Programmed cell death 1/programmed death ligand 1 (PD-1/PD-L1) immune-checkpoint blockade is a promising new therapeutic strategy in cancer. However, expression patterns and prognostic significance of PD-L1 and PD-1 are still controversial in human malignant pleural mesothelioma (MPM). Methods: Formalin-fixed paraffin-embedded (FFPE) tumor samples from 203 MPM patients receiving standard treatment without immunotherapy were collected from 5 European centers. PD-L1 and PD-1 expression of tumor cells (TCs) and tumor-infiltrating lymphocytes (TILs) were measured by immunohistochemistry and correlated with clinical parameters and long-term outcome. Results: High (>10%) PD-L1 TC and PD-1 TILs expressions were found in 18 (8%) and 39 (24%) patients, respectively. PD-L1 was rarely expressed by TILs [>/=1%, n=13 (8%); >10%, n=1]. No significant associations were found between the PD-L1 or PD-1 expression of TCs or TILs and clinicopathological parameters such as stage or histological subtype. Notably, patients with high (>10%) TC-specific PD-L1 expression exhibited significantly worse median overall survival (OS) (6.3 vs. 15.1 months of those with low TC PD-L1 expression; HR: 2.51, P<0.001). In multivariate cox regression analysis adjusted for clinical parameters, high TC PD-L1 expression (>10%) proved to be an independent negative prognostic factor for OS (HR: 2.486, P=0.005). There was no significant correlation between PD-L1 or PD-1 expression of TILs and OS. Conclusions: In this multicenter cohort study, we demonstrate that high (>10%) PD-L1 expression of TCs independently predicts worse OS in MPM. Further studies are warranted to investigate the value of PD-L1/PD-1 expression as a marker for treatment response in MPM patients receiving immunotherapy.
Ključne besede: mesothelioma - anatomy and histology - analysis, 1malignant pleural mesothelioma, programmed death-ligand 1, programmed cell death 1, PD-L1
DiRROS - Objavljeno: 31.03.2021; Ogledov: 27; Prenosov: 7
URL Celotno besedilo (0,00 KB)

77.
Can we use dendrogeomorphology for the spatial and temporal analysis of less intensive mass movement processes?: Acase study of three debris flows in NW and W Slovenia
Matevž Konjar, Tom Levanič, Thomas Andrew Nagel, Milan Kobal, 2021

Povzetek: Debris flows can transport large amounts of material and therefore present a significant threat to infrastructure and human life. In this research, we used tree-ring width analyses to quantify the response of trees to three debris flow events in NW Slovenia (Javoršček, Srpenica) and W Slovenia (Nikova) for which we know the time of origin. We attempted to date these and similar tree responses in the past and compared the patterns between different tree species. Altogether, we sampled 147 trees across a range of tree species (Fagus sylvatica, Pinus sylvestris, Fraxinus excelsior, Fraxinus ornus, Acer pseudoplatanus, Picea abies, Juglans regia, Acer campestre, Tilia cordata and Ostrya carpinifolia), including reference trees that were outside the debris flow fan. For 91 trees, we constructed tree-ring chronologies and used pointer-year analysis to identify years that had abnormal growth. For the remaining trees (mostly Ostrya carpinifolia, Tilia cordata and Acer pseudoplatanus), we either could not accurately distinguish tree rings or two samples from a single tree showed significantly different growth patterns. The growth patterns of Fagus sylvatica and Picea abies following debris flow events showed a weak response at the Javoršček site and no clear responses at the other two sites. Tree species responded similarly at the same locations. Due to the lack of a clear response pattern, we were not able to reconstruct past debris flows.
Ključne besede: debris flows, tree rings, dendrogeomorphology, slope processes
DiRROS - Objavljeno: 30.03.2021; Ogledov: 108; Prenosov: 27
.pdf Celotno besedilo (6,49 MB)

78.
Gozdarska znanost za prihodnje gozdove : gozdni genetski monitoring in biotska raznovrstnost v spreminjajočem se okolju : LIFEGENMON zaključna konferenca : knjiga povzetkov
2020

Povzetek: V zborniku so zbrani povzetki predavanj in predstavitev konferenčnih plakatov.
Ključne besede: zborniki, povzetki, elektronske knjige
DiRROS - Objavljeno: 29.03.2021; Ogledov: 53; Prenosov: 17
.pdf Celotno besedilo (903,48 KB)

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Usklajena merila sprejemljive poškodovanosti gozdnih tal - preverjanje ustreznosti med gozdarskimi strokovnjaki
Anton Poje, Matevž Mihelič, Vasja Leban, 2021

Povzetek: Splošno veljavna, predvsem pa v stroki sprejeta merila sprejemljive poškodovanosti tal po gozdni proizvodnji so predpogoj za učinkovito varovanje gozdnih tal in objektiven nadzor nad kakovostjo izvedbe gozdnih del. V raziskavi znotraj gozdarske stroke smo preverili sprejemljivost meril, ki so jih na osnovi dosedanjih raziskav predlagali Poje in sodelavci (2019). Anketiranje je bilo opravljeno na 35. Gozdarskih študijskih dnevih, kjer je na anketo odgovorilo 62 udeležencev iz različnih ustanov. Rezultati ankete so pokazali, da so usklajena merila strožja od predlaganih ter da se ocene po posameznih kazalnikih znotraj meril razlikujejo med deležniki. Po predlogu usklajenih meril je dopustna odprtost z vlakami 192 m/ha, s sečnimi potmi pa dodatnih 193 m/ha. Največja globina kolesnic na vlakah ne sme presegati 30 cm, na sečnih poteh pa 20 cm. Največja globina kolesnic na 90 % dolžine vseh sečnih poti na delovišču naj ne presega 10 cm. Tudi na osnovi rezultatov drugih študij se zdi predlog usklajenih meril smiseln in primeren s tehnološkega, ekonomskega in ekološkega vidika. Pred uvajanjem usklajenih meril v prakso je poleg njihovega preverjanja na terenu in morebitnega ponovnega usklajevanja treba nujno razviti metodo za ocenjevanje poškodovanosti.
Ključne besede: pridobivanje lesa, anketa, merila sprejemljive poškodovanosti tal, poškodba tal
DiRROS - Objavljeno: 28.03.2021; Ogledov: 80; Prenosov: 37
.pdf Celotno besedilo (970,42 KB)

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