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1.
Breast cancer risk prediction using Tyrer-Cuzick algorithm with an 18-SNPs polygenic risk score in a European population with below-average breast cancer incidence
Tjaša Oblak, Petra Škerl, Benjamin J. Narang, Rok Blagus, Mateja Krajc, Srdjan Novaković, Janez Žgajnar, 2023, izvirni znanstveni članek

Povzetek: Goals: To determine whether an 18 single nucleotide polymorphisms (SNPs) polygenic risk score (PRS18) improves breast cancer (BC) risk prediction for women at above-average risk of BC, aged 40-49, in a Central European population with BC incidence below EU average. Methods: 502 women aged 40-49 years at the time of BC diagnosis completed a questionnaire on BC risk factors (as per Tyrer-Cuzick algorithm) with data known at age 40 and before BC diagnosis. Blood samples were collected for DNA isolation. 250 DNA samples from healthy women aged 50 served as a control cohort. 18 BC-associated SNPs were genotyped in both groups and PRS18 was calculated. The predictive power of PRS18 to detect BC was evaluated using a ROC curve. 10-year BC risk was calculated using the Tyrer-Cuzick algorithm adapted to the Slovenian incidence rate (S-IBIS): first based on questionnaire-based risk factors and, second, including PRS18. Results: The AUC for PRS18 was 0.613 (95 % CI 0.570-0.657). 83.3 % of women were classified at above-average risk for BC with S-IBIS without PRS18 and 80.7 % when PRS18 was included. Conclusion: BC risk prediction models and SNPs panels should not be automatically used in clinical practice in different populations without prior population-based validation. In our population the addition of an 18SNPs PRS to questionnaire-based risk factors in the Tyrer-Cuzick algorithm in general did not improve BC risk stratification, however, some improvements were observed at higher BC risk scores and could be valuable in distinguishing women at intermediate and high risk of BC.
Ključne besede: early breast cancer, polygenic risk score, risk prediction
Objavljeno v DiRROS: 21.03.2024; Ogledov: 72; Prenosov: 26
.pdf Celotno besedilo (1,54 MB)

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Sensitivity analysis of RF+clust for leave-one-problem-out performance prediction
Ana Nikolikj, Michal Pluhacek, Carola Doerr, Peter Korošec, Tome Eftimov, 2023, objavljeni znanstveni prispevek na konferenci

Ključne besede: automated performance prediction, autoML, single-objective black-box optimization, zero-shot learning
Objavljeno v DiRROS: 13.11.2023; Ogledov: 313; Prenosov: 187
.pdf Celotno besedilo (4,94 MB)
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4.
MsGEN : measuring generalization of nutrient value prediction across different recipe datasets
Gordana Ispirova, Tome Eftimov, Sašo Džeroski, Barbara Koroušić-Seljak, 2023, izvirni znanstveni članek

Povzetek: In this study, we estimate the generalization of the performance of previously proposed predictive models for nutrient value prediction across different recipe datasets. For this purpose, we introduce a quantitative indicator that determines the level of generalization of using the developed predictive model for new unseen data not presented in the training process. On a predefined corpus of recipe embeddings from six publicly available recipe datasets (i.e., projecting them in the same meta-feature vector space), we train predictive models on one of the six recipe datasets and test the models on the rest of the datasets. In parallel, we define and calculate generalizability indexes which are numbers that indicate how generalizable a predictive model is i.e., how well will a predictive model learned on one dataset perform on another one not involved in the training. The evaluation results prove the validity of these indexes – their relation with the accuracy of the predictions. Further, we define three sampling techniques for selecting representative data instances that will cover all parts from the feature space uniformly (involving data from all datasets) and further will improve the generalization of a predictive model. We train predictive models with these generalized datasets and test them on instances from the six recipe datasets that are not selected and included in the generalized datasets. The results from the evaluation of these predictive models show improvement compared to the results from the predictive models trained on one recipe dataset and tested on the others separately.
Ključne besede: ML pipeline, predictive modeling, nutrient prediction, recipe datasets
Objavljeno v DiRROS: 25.09.2023; Ogledov: 380; Prenosov: 179
.pdf Celotno besedilo (3,27 MB)
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5.
RF+clust for leave-one-problem-out performance prediction
Ana Nikolikj, Carola Doerr, Tome Eftimov, 2023, objavljeni znanstveni prispevek na konferenci

Ključne besede: algorithm performance prediction, automated machine learning, zero-shot learning, black-box optimization
Objavljeno v DiRROS: 30.08.2023; Ogledov: 324; Prenosov: 105
.pdf Celotno besedilo (4,47 MB)
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6.
Impact of leaching on chloride ingress profiles in concrete
Alisa Machner, Marie Helene Bjørndal, Aljoša Šajna, Nikola Mikanovic, Klaartje De Weerdt, 2022, izvirni znanstveni članek

Povzetek: To investigate the effect of leaching on chloride ingress profiles in concrete and mortar, we exposed concrete and mortar specimens for 90 and 180 days to two different exposure solutions: 3% NaCl, and 3% NaCl with KOH added to limit leaching. The solutions were replaced weekly. After exposure, we determined total chloride profiles to investigate the chloride ingress, and portlandite profiles to assess the extent of leaching. The results showed that leaching during exposure greatly affects the chloride ingress profiles in mortar and concrete. We found that leaching leads to considerably higher maximum total chloride content and deeper chloride penetration into the concrete than in the specimens where leaching was limited. We recommend therefore that leaching should be taken into account in standard laboratory testing and that more mechanistic service life models should be used to take into account the impact of leaching.
Ključne besede: chloride ingress, service life prediction, leaching, concrete, portlandite, open access
Objavljeno v DiRROS: 04.05.2023; Ogledov: 277; Prenosov: 173
.pdf Celotno besedilo (1,17 MB)
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7.
Leaching and geochemical modelling of an electric arc furnace (EAF) and ladle slag heap
Mojca Loncnar, Ana Mladenovič, Vesna Zalar Serjun, Marija Zupančič, Hans A. van der Sloot, 2022, izvirni znanstveni članek

Povzetek: Old metallurgical dumps across Europe represent a loss of valuable land and a potential threat to the environment, especially to groundwater (GW). The Javornik electric arc furnace (EAF) and ladle slag heap, situated in Slovenia, was investigated in this study. The environmental impact of the slag heap was evaluated by combining leaching characterization tests of landfill samples and geochemical modelling. It was shown that throughout the landfill the same minerals and sorptive phases control the leaching of elements of potential concern, despite variations in chemical composi- tion. Although carbonation of the disposed steel slags occurred (molar ratio CO3/(Ca+Mg) = 0.53) relative to fresh slag, it had a limited effect on the leaching behaviour of elements of potential concern. The leaching from the slag heaps had also a limited effect on the quality of the GW. A site-specific case, however, was that leachates from the slag heap were strongly diluted, since a rapid flow of GW fed from the nearby Sava River was observed in the landfill area. The sampling and testing approach applied provides a basis for assessing the long-term impact of release and is a good starting point for evaluating future management options, including beneficial uses for this type of slag.
Ključne besede: EAF slag, field verification, geochemical modelling, ladle slag, leaching, release prediction, steel slag heap
Objavljeno v DiRROS: 28.04.2023; Ogledov: 338; Prenosov: 182
.pdf Celotno besedilo (4,37 MB)
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8.
Prediction of actual from climatic precipitation with data collected from northern Poland : a statistical approach
Jacek Barańczuk, Martina Zeleňáková, Hany F. Abd-Elhamid, Katarzyna Barańczuk, Salem S. Gharbia, Peter Blišťan, Cécil J. W. Meulenberg, Peter Kumer, Włodzimierz Golus, Maciej Markowski, 2023, izvirni znanstveni članek

Povzetek: Water is a basic element of the natural environment and the most important component in human water management. Rainfall is the main source of water. Therefore, determining the amount of precipitation reaching the ground using sensors is crucial information. Precise precipitation data are necessary for better modeling quality, as the observation data from weather stations are used as basics for weather model assessment. The authors compared precipitation from the Hellmann rain gauge (climatic precipitation, 1.0 m above the ground surface) measured throughout the year and the GGI 3000 rain gauge (actual precipitation on the ground level) measured from April to October. Measurement sequences from the years 2011–2020 were considered. The data for analysis were obtained from a weather station located in northern Poland. The authors analyzed the relationships between data from the two sensors. A comparative study showed that the measurements of actual precipitation are higher and there are strong relationships between actual and climatic rainfall (r = 0.99). Using the introduced coefficient it is possible to determine the full–year actual precipitation with high probability, taking into account the precipitation with a correction from the winter half-year and the actual precipitation from the summer half-year, which is of great importance in the calculation of the water balance.
Ključne besede: natural environment, climate change, precipitation, prediction, statistics, analysis, Poland
Objavljeno v DiRROS: 25.01.2023; Ogledov: 376; Prenosov: 230
.pdf Celotno besedilo (2,74 MB)
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9.
Impact of climate change on landslides in Slovenia in the mid-21st century
Mateja Jemec Auflič, Gašper Bokal, Špela Kumelj, Anže Medved, Mojca Dolinar, Jernej Jež, 2021, izvirni znanstveni članek

Povzetek: Slovenia is affected by extreme and intense rainfall that triggers numerous landslides every year, resulting in significant human impact and damage to infrastructure. Previous studies on landslides have shown how rainfall patterns can influence landslide occurrence, while in this paper, we present one of the first study in Slovenia to examine the impact of climate change on landslides in the mid-21st century. To do this, we used the Representative Concentration Pathway (RCP) 4.5 climate scenario and future climatology simulated by six climate models that differed from each other as much as possible while representing measured values of past climate variables as closely as possible. Based on baseline period (1981-2010) we showed the number of days with exceedance of rainfall thresholds and the area where landslides may occur more frequently in the projection period (2041-2070). We found that extreme rainfall events are likely to occur more frequent in the future, which may lead to a higher frequency of landslides in some areas.
Ključne besede: climate change, landslides, models, hazard, prediction
Objavljeno v DiRROS: 09.03.2022; Ogledov: 783; Prenosov: 300
.pdf Celotno besedilo (4,78 MB)

10.
Combining an occurrence model and a quantitative model for the prediction of the sanitary felling of Norway spruce because of bark beetles
Maarten De Groot, Nikica Ogris, 2022, izvirni znanstveni članek

Povzetek: The European spruce bark beetle (Ips typographus L.) is an eruptive forest pest that has caused a great deal of damage in the last decades because of increasing climatic extremes. In order to effectively manage outbreaks of this pest, it is important to predict where they will occur in the future. In this study we developed a predictive model of the sanitary felling of Norway spruce (Picea abies (L.) H. Karst.) because of bark beetles. We used a time series of sanitary felling because of bark beetles from 1996 to 2020 in Slovenia. For the explanatory variables, we used soil, site, climate, geographic, and tree damage data from the previous year. The model showed that sanitary felling is negatively correlated with slope, soil depth, soil cation exchange capacity, and Standard Precipitation Index (less sanitary felling in wet years). On the other hand, soil base saturation percentage, temperature, sanitary felling because of bark beetles from the previous year, sanitary felling because of other abiotic factors from the previous year, and the amount of spruce were positively correlated with the sanitary felling of Norway spruce due to bark beetles. The model had an R2 of 0.38. A prediction was performed for 2021 combining an occurrence model and a quantitative model. The model can be used to predict the amount of sanitary felling of Norway spruce due to bark beetles and to refine the risk map for the next year, which can be used for forest management planning and economic loss predictions.
Ključne besede: sanitary felling, prediction, Ips typographus, Picea abies, Slovenia, forecasting, insect outbreak forest pest
Objavljeno v DiRROS: 21.02.2022; Ogledov: 628; Prenosov: 516
.pdf Celotno besedilo (1,24 MB)
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