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1.
Inhibition of cathepsin X enzyme influences the immune response of THP-1 cells and dendritic cells infected with Helicobacter pylori
Miha Skvarč, David Štubljar, Andreja Nataša Kopitar, Samo Jeverica, Bojan Tepeš, Janko Kos, Alojz Ihan, 2013, izvirni znanstveni članek

Povzetek: Background. The immune response to Helicobacter pylori importantly determines the outcome of infection as well as the success of eradication therapy. We demonstrate the role of a cysteine protease cathepsin X in the immune response to H. pylori infection. Materials and methods. We analysed how the inhibition of cathepsin X influenced the immune response in experiments when THP-1 cells or dendritic cells isolated from patients were stimulated with 48 strains of H. pylori isolated from gastric biopsy samples of patients which had problems with the eradication of bacteria. Results. The experiments, performed with the help of a flow cytometer, showed that the expression of Toll-like receptors (TLRs), especially TLR-4 molecules, on the membranes of THP-1 cells or dendritic cells was higher when we stimulated cells with H. pylori together with inhibitor of cathepsin X 2F12 compared to THP-1 cells or dendritic cells stimulated with H. pylori only, and also in comparison with negative control samples. We also demonstrated that when we inhibited the action of cathepsin X in THP-1 cells, the concentrations of pro-inflammatory cytokines were lower than when THP-1 cell were stimulated with H. pylori only. Conclusions. We demonstrated that inhibition of cathepsin X influences the internalization of TLR-2 and TLR-4. TLR-2 and TLR-4 redistribution to intra-cytoplasmic compartments is hampered if cathepsin X is blocked. The beginning of a successful immune response against H. pylori in the case of cathepsin X inhibition is delayed.
Ključne besede: cathepsin X, macrophage, dendritic cells
Objavljeno v DiRROS: 22.03.2024; Ogledov: 42; Prenosov: 24
.pdf Celotno besedilo (564,38 KB)
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2.
Long term follow-up report of cardiac toxicity in patients with multiple myeloma treated with tandem autologous hematopoietic stem cell transplantation
Mirta Koželj, Samo Zver, Vesna Zadnik, 2013, izvirni znanstveni članek

Povzetek: Background. Tandem autologous hematopoietic stem cell transplantation (ta-HSCT) is a standard treatment for multiple myeloma (MM). Patients receive a high-dose cyclophosphamide (CY), followed by two myeloablative cycles of melphalan (MEL). There are scarce data about long term cardiotoxicity. Patients and methods. We studied 12 patients (62.25 8.55 years) six years after the completion of MM treatment with ta-HCST. Late cardiotoxic effects were evaluated clinically and echocardiographically. Results. None of the patients developed clinical signs of heart failure, all were in sinus rhythm and NT-pro BNP concentration was elevated (778 902.76 pg/mL). The left ventricular (LV) size remained normal. The LV ejection fraction did not decrease (73.75 5.67%, 69.27 6.13%, p = NS). The LV diastolic function parameters (E, A, ratio E/A and A/a) did not change significantly. In tissue Doppler parameters we observed a nonsignificant decrease in Em (10.26 2.63 cm/s, 7.57 1.43 cm/s) and Sm velocities (8.7 0.87 cm/s, 7.14 1.17 cm/s, p = NS). The E/Em values were in an abnormal range (8.66 1.05, 10.55 2.03). Conclusions. The treatment of MM with ta-HSCT, during which patients receive a high dose CY followed by two myeloablative cycles of MEL, causes mild, chronic, partially reversible and clinically silent cardiotoxic side-effects. However, ta-HSCT in patients with MM is a safe regarding cardiotoxic side effects, but, because of increasing life expectancy needs long term attention.
Ključne besede: cardiotoxicity, echocardiography, myeloma
Objavljeno v DiRROS: 22.03.2024; Ogledov: 42; Prenosov: 17
.pdf Celotno besedilo (288,46 KB)

3.
Generalized cut method for computing Szeged-like polynomials with applications to polyphenyls and carbon nanocones
Simon Brezovnik, Niko Tratnik, 2023, izvirni znanstveni članek

Povzetek: Szeged, Padmakar-Ivan (PI), and Mostar indices are some of the most investigated distance-based Szeged-like topological indices. On the other hand, the polynomials related to these topological indices were also introduced, for example the Szeged polynomial, the edge- Szeged polynomial, the PI polynomial, the Mostar polynomial, etc. In this paper, we introduce a concept of the general Szeged-like polynomial for a connected strength-weighted graph. It turns out that this concept includes all the above mentioned polynomials and also infinitely many other graph polynomials. As the main result of the paper, we prove a cut method which enables us to efficiently calculate a Szeged-like polynomial by using the corresponding polynomials of strength-weighted quotient graphs obtained by a partition of the edge set that is coarser than ▫$\Theta^*$▫-partition. To the best of our knowledge, this represents the first implementation of the famous cut method to graph polynomials. Finally, we show how the deduced cut method can be applied to calculate some Szeged-like polynomials and corresponding topological indices of para-polyphenyl chains and carbon nanocones.
Ključne besede: graph theory, carbon nanocone, topological indices
Objavljeno v DiRROS: 20.03.2024; Ogledov: 62; Prenosov: 20
.pdf Celotno besedilo (599,00 KB)

4.
Resonance graphs and a binary coding of perfect matchings of outerplane bipartite graphs
Simon Brezovnik, Niko Tratnik, Petra Žigert Pleteršek, 2023, izvirni znanstveni članek

Povzetek: The aim of this paper is to investigate resonance graphs of $2$-connected outerplane bipartite graphs, which include various families of molecular graphs. Firstly, we present an algorithm for a binary coding of perfect matchings of these graphs. Further, $2$-connected outerplane bipartite graphs with isomorphic resonance graphs are considered. In particular, it is shown that if two $2$-connected outerplane bipartite graphs are evenly homeomorphic, then its resonance graphs are isomorphic. Moreover, we prove that for any $2$-connected outerplane bipartite graph $G$ there exists a catacondensed even ring systems $H$ such that the resonance graphs of $G$ and $H$ are isomorphic. We conclude with the characterization of $2$-connected outerplane bipartite graphs whose resonance graphs are daisy cubes.
Ključne besede: graph theory, resonance graphs, bipartite graphs
Objavljeno v DiRROS: 18.03.2024; Ogledov: 54; Prenosov: 23
.pdf Celotno besedilo (433,15 KB)

5.
Outerplane bipartite graphs with isomorphic resonance graphs
Simon Brezovnik, Zhongyuan Che, Niko Tratnik, Petra Žigert Pleteršek, 2024, izvirni znanstveni članek

Povzetek: We present novel results related to isomorphic resonance graphs of 2-connected outerplane bipartite graphs. As the main result, we provide a structure characterization for 2-connected outerplane bipartite graphs with isomorphic resonance graphs. Three additional characterizations are expressed in terms of resonance digraphs, via local structures of inner duals, as well as using distributive lattices on the set of order ideals of posets defined on inner faces of 2-connected outerplane bipartite graphs.
Ključne besede: distributive lattice, inner dual, isomorphic resonance graphs, order ideal, 2-connected outerplane bipartite graph
Objavljeno v DiRROS: 13.03.2024; Ogledov: 63; Prenosov: 35
.pdf Celotno besedilo (452,02 KB)
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Effect of heat treatment on thermal conductivity of additively manufactured AISI H13 tool steel
Samo Tome, Blaž Karpe, Irena Paulin, Matjaž Godec, 2024, objavljeni znanstveni prispevek na konferenci

Povzetek: AISI H13 is commonly used for tooling, where higher wear resistance, thermal fatigue resistance, or hot toughness is required. Such examples include forging dies, plastic molds, hot shear blades, high-pressure die casting, and extrusion dies. Thus, thermal conductivity is one of the most important factors for hot work tools. Typically, the work cycle of a hot work tool designed for forging consists of four main phases: the forging stroke, with which the die imparts its shape onto the part, a brief pause while the die is reset to its original position, a lubrication phase, and a post lubrication dwell phase. During the forging phase, a significant amount of heat is transferred to the die while it is in contact with the part. This heat must then be dispelled for the part to return to a working temperature. While somewhat different, other hot work processes mentioned above are similar in that the hot work tool gets heated to a high temperature due to the contact with the object of deformation. The process of additive manufacturing (AM) promises better, more efficient tool production with features like conforming cooling channels, which would reduce the thermal fatigue of tools, prolonging tool life. However, the powder bed fusion (PBF) method creates a columnar microstructure, which has a detrimental effect on the thermal conductivity of H13 tool steel. Our investigation focused on the beneficial effect of heat treatment, specifically annealing at different temperatures, on the thermal conductivity of AM-produced H13 parts.
Ključne besede: SLM, thermal conductivity, tool steel, heat treatment
Objavljeno v DiRROS: 28.02.2024; Ogledov: 82; Prenosov: 43
.pdf Celotno besedilo (655,96 KB)
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Apparatus for positron emission tomography
Marko Starič, Samo Korpar, Erik Margan, Marko Šifrar, Aleš Stanovnik, Nataša Budihna, Metka Milčinski, Boris Šket, 1998, izvirni znanstveni članek

Objavljeno v DiRROS: 19.01.2024; Ogledov: 143; Prenosov: 37
.pdf Celotno besedilo (693,52 KB)

10.
Parametarska studija kolničke konstrukcije ojačane geoćelijama
Samo Peter Medved, Bojan Žlender, Stanislav Lenart, 2018, izvirni znanstveni članek

Povzetek: U radu je prikazano parametarsko ispitivanje kolničke konstrukcije ojačane geoćelijama. Analiza temeljena na metodi konačnih elemenata uključuje model neojačane kolničke konstrukcije te model kolničke konstrukcije ojačane geoćelijama, pri čemu se analiziraju razni položaji, debljine i čvrstoća geoćelija. U okviru modela određen je i očekivani vijek trajanja kolničke konstrukcije. Rezultati parametarskog proučavanja u skladu su s rezultatima analitičkih rješenja, laboratorijskih i terenskih ispitivanja. Dobiveni rezultati upućuju na bitno poboljšanje nosivosti, smanjenje debljine asfaltnih slojeva i povećanje trajnosti kolničke konstrukcije kada je ona ojačana geoćelijama.
Objavljeno v DiRROS: 12.12.2023; Ogledov: 143; Prenosov: 96
.pdf Celotno besedilo (444,79 KB)
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