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Iskalni niz: "avtor" (Miha De%C5%BEman) .

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1.
Contaminant trends in urban groundwater: case study from Ljubljana (central Slovenia)
Janja Svetina, Joerg Prestor, Brigita Jamnik, Primož Auersperger, Mihael Brenčič, 2024, izvirni znanstveni članek

Povzetek: Urban areas can significantly alter the quality status of aquifers if appropriate strategies to prevent and detect groundwater contamination are not implemented in time. The prevention of groundwater contamination should be a priority due to its potential long-term impact on the environment and the high cost of remediation. For effective and sustainable groundwater management, it is crucial to proactively monitor a wide range of compounds to prevent their spread, progression and increasing concentrations. This study is one of the few to analyse the trends of various urban groundwater contaminants (nitrate, sulphate, hexavalent chromium, pesticides, PCE and TCE) from a groundwater management perspective. Characteristic trends are assessed using linear regression and the Mann–Kendall method, while significant changes in trends are determined using the Darken and Pettitt tests. The time span of the analysed trends covers the transition period before and after the implementation of the Water Framework Directive (2000/60/EC) and the Groundwater Directive (2000/60/EC). This study confirms the effectiveness of enforcement measures to protect groundwater quality, as evidenced by several statistically significant decreasing trends. On the other hand, this study emphasises the importance of intervention-targeted sampling campaigns and the reporting of raw analytical values according to the ISO 11843 series of standards. This approach is essential to detect upward trends in emerging contaminants at an early stage and prevent them from reaching levels that could negatively impact the economy or even jeopardise the safety of drinking water supplies.
Ključne besede: groundwater contamination, contaminant trends, groundwater management, urban aquifer, Ljubljansko polje
Objavljeno v DiRROS: 25.03.2024; Ogledov: 38; Prenosov: 11
.pdf Celotno besedilo (7,36 MB)

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Inhibition of cathepsin X enzyme influences the immune response of THP-1 cells and dendritic cells infected with Helicobacter pylori
Miha Skvarč, David Štubljar, Andreja Nataša Kopitar, Samo Jeverica, Bojan Tepeš, Janko Kos, Alojz Ihan, 2013, izvirni znanstveni članek

Povzetek: Background. The immune response to Helicobacter pylori importantly determines the outcome of infection as well as the success of eradication therapy. We demonstrate the role of a cysteine protease cathepsin X in the immune response to H. pylori infection. Materials and methods. We analysed how the inhibition of cathepsin X influenced the immune response in experiments when THP-1 cells or dendritic cells isolated from patients were stimulated with 48 strains of H. pylori isolated from gastric biopsy samples of patients which had problems with the eradication of bacteria. Results. The experiments, performed with the help of a flow cytometer, showed that the expression of Toll-like receptors (TLRs), especially TLR-4 molecules, on the membranes of THP-1 cells or dendritic cells was higher when we stimulated cells with H. pylori together with inhibitor of cathepsin X 2F12 compared to THP-1 cells or dendritic cells stimulated with H. pylori only, and also in comparison with negative control samples. We also demonstrated that when we inhibited the action of cathepsin X in THP-1 cells, the concentrations of pro-inflammatory cytokines were lower than when THP-1 cell were stimulated with H. pylori only. Conclusions. We demonstrated that inhibition of cathepsin X influences the internalization of TLR-2 and TLR-4. TLR-2 and TLR-4 redistribution to intra-cytoplasmic compartments is hampered if cathepsin X is blocked. The beginning of a successful immune response against H. pylori in the case of cathepsin X inhibition is delayed.
Ključne besede: cathepsin X, macrophage, dendritic cells
Objavljeno v DiRROS: 22.03.2024; Ogledov: 42; Prenosov: 22
.pdf Celotno besedilo (564,38 KB)
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3.
Outcome of MRI-guided vacuum-assisted breast biopsy - initial experience at Institute of Oncology Ljubljana, Slovenia
Marta Zebič, Kristijana Hertl, Maksimiljan Kadivec, Miha Čavlek, Gašper Podobnik, Marko Snoj, 2012, izvirni znanstveni članek

Povzetek: Background. Like all breast imaging modalities MRI has limited specificity and the positive predictive value for lesions detected by MRI alone ranges between 15 and 50%. MRI guided procedures (needle biopsy, presurgical localisation) are mandatory for suspicious findings visible only at MRI, with potential influence on therapeutic decision. The aim of this retrospective study was to evaluate our initial clinical experience with MRI-guided vacuum-assisted breast biopsy as an alternative to surgical excision and to investigate the outcome of MRI-guided breast biopsy as a function of the MRI features of the lesions. Patients and methods. In 14 women (median age 51 zears) with 14 MRI-detected lesions, MRI-guided vacuum-assisted breast biopsy was performed. We evaluated the MRI findings that led to biopsy and we investigated the core and postoperative histology results and follow-up data. Results. The biopsy was technically successful in 14 (93%) of 15 women. Of 14 biopsies in 14 women, core histology revealed 6 malignant (6/14, 43%), 6 benign (6/14, 43%) and 2 high-risk (2/14, 14%) lesions. Among the 6 cancer 3 were invasive and 3 were ductal carcinoma in situ (DCIS). The probability of malignancy in our experience was higher for non-mass lesion type and for washout and plateau kinetics. Conclusions. Our initial experience confirms that MRI-guided vacuum-assisted biopsy is fast, safe and accurate alternative to surgical biopsy for breast lesions detected at MRI only.
Objavljeno v DiRROS: 21.03.2024; Ogledov: 50; Prenosov: 20
.pdf Celotno besedilo (617,87 KB)

4.
Imaging findings in bisphosphonate-induced osteonecrosis of the jaws
Katarina Šurlan Popović, Miha Kočar, 2010, izvirni znanstveni članek

Ključne besede: rak (medicina), bisfosfonati, radiologija, zdravljenje, čeljustnica, nekroze, diagnostika
Objavljeno v DiRROS: 18.03.2024; Ogledov: 51; Prenosov: 22
.pdf Celotno besedilo (737,45 KB)

5.
Is there any progress in routine management of lung cancer patients? A comparative analysis of an institution in 1996 and 2006
Lučka Debevec, Tina Jerič, Viljem Kovač, Marko Bitenc, Mihael Sok, 2009, izvirni znanstveni članek

Povzetek: Background. The aim of the study was to establish eventual progress in routine management of lung cancer patients over a ten-year period at University Clinic for Respiratory and Allergic Diseases Golnik, Slovenia, comparing the results of analysis of 345 patients, diagnosed in 1996 (with analysis performed in 2002), and 405 patients, diagnosed in 2006 (with analysis performed in 2008).Patients and methods. The patients of both analysed groups were of comparable age and number of patients in stage I and II, but there were relatively more females, patients with better performance status, more precise clinical staging and tumour histology in the 2006 group. The parameters used for assessing the progress of management were as follows: time period from admittance to diagnosis and to surgery; precision of staging; accordance of clinical and pathological staging in resected patients; percentage of exploratory thoracotomy; and use of new treatment modalities. The proportion of patients in selected/actual primary treatment modality and survival rate could also be used for assessing the progress. Results. Althoughunessential longer time from admittance to microscopic confirmed diagnosis increased from a mean 7.4 to 8.6 days in 2006 progress was established by the following: more precise clinical staging (stage I and II also A and B stage, TNM staging also in small-cell lung cancer patients); improved accordance with clinical and pathological staging in resected patients (46% against 58%); decreased percentage of exploratory thoracotomy (13% against 4%); increased use of multimodality therapy as primary treatment modality (radiotherapy/chemotherapy, neoadjuvant chemotherapy); newly performed radio frequency tumour ablation. The proportion in selected/actual surgery increased from 76% to 93% and median survival rate of all patients from 6.2 to 10.6 months. (Abstract truncated at 2000 characters)
Objavljeno v DiRROS: 08.03.2024; Ogledov: 70; Prenosov: 22
.pdf Celotno besedilo (80,75 KB)

6.
Difference between using tabulated and exact values of thermal properties of materials in numerical simulations of heat transfer through a high-performance window
Miha Jukić, Sabina Jordan, 2019, objavljeni znanstveni prispevek na konferenci

Povzetek: The thermal properties of materials, primarily the thermal conductivity, are an essential input for numerical modelling of heat transfer in buildings and building components. When determining them according to relevant European standards, it is not uncommon to encounter materials for which the exact values are not appropriately specified and the tabulated values in standards are overly conservative. In such situations, the thermal conductivity of the material can be determined by measurement. However, this approach may prove inconvenient and too expensive, especially if the material in question turns out to have little influence on the overall thermal performance of the product. It is, therefore, of great interest to know how the thermal performance is affected by choosing either the accurate (measured) or the conservative (tabulated) value of the thermal conductivity. In this work, the two approaches are compared in a practical example – a high-performance window, Jelovica Jelofuture – using numerical simulations. Our study shows that modifying the thermal properties of individual materials generally leaves the thermal transmittances of the frame (Uf) and the window (UW) almost unaffected. If all of the materials considered are modified simultaneously, Uf changes by 1–2% while the change in UW remains below 1%. However, due to their small values, the calculated changes of Uf and UW may be significantly affected (further increased or reduced) by the rounding of the results according to the relevant standards. In contrast, using the tabulated value of linear thermal transmittance (Ψg) of the junction with the glazing leads to an overestimation of UW by up to 15%.
Ključne besede: thermal transmittance, numerical simulation, conductivity, tabulated and exact values, practical example
Objavljeno v DiRROS: 08.03.2024; Ogledov: 57; Prenosov: 37
.pdf Celotno besedilo (282,29 KB)
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Preoperative concomitant chemoradiotherapy in esophageal cancer
Boštjan Šeruga, Mihael Sok, Janez Eržen, Jože Jerman, Boris Jančar, Branko Zakotnik, 2006, izvirni znanstveni članek

Povzetek: Background. Currently primary treatment options for esophageal cancer are surgery only or concomitant chemoradiotherapy (CRT) and the long-term survivalof patients with locally advanced disease is rare. Preoperative concomitant CRT seems to be beneficial, mostly in patients who achieve a complete pathologic response (pCR) after CRT. In this retrospective analysis the efficiency and toxicity of preoperative CRT in patients with locally advanced esophageal cancer was analysed as well as the influence of pCR on thesuraival. Patients and metkods From 1996 to 2002 41 patients with locoregionally confined esophageal cancerwere treated with cisplatin 75 mgžm2 and 5-FU 1000 mgžm2 as 4 day contonuous infusion starting on days 1. and 22. with concorrtitant radiotherapy 4500 cGy, 200-300 cGyžday. Esophagectomy followed 4-5 weeks after radiotherapy. After the surgery patients were followed-up regularly at 3-6 months intervals. Results. The pCR was achieved in 26.8% of patients. The overall median survival time was 18 months for all patients, 21.2 months for patients who achieved pCR and 16 months in those with residual disease (p= 0,79). Postoperative mortality rate was 22%. The median dose intensity for cisplatin was 92% and for 5-FU 71.5 of the planned dose. Disease recurred most often locoregionally (31.7%) and the overall recurrence rate was 43.9. Conclusion. Modern radiation techniques and the adequate dose intensity could further improve the locoregional control. The selection of patients without comorbid conditions and without already present distant metastases is essential for this combined treatment approach.
Objavljeno v DiRROS: 15.02.2024; Ogledov: 100; Prenosov: 25
.pdf Celotno besedilo (123,83 KB)

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