1. Bevacizumab and irinotecan in recurrent malignant glioma, a single institution experienceTanja Mesti, Maja Ebert Moltara, Marko Boc, Martina Reberšek, Janja Ocvirk, 2015, izvirni znanstveni članek Povzetek: Treatment options of recurrent malignant gliomas are very limited and with a poor survival benefit. The results from phase II trials suggest that the combination of bevacizumab and irinotecan is beneficial. Patients and methods. The medical documentation of 19 adult patients with recurrent malignant gliomas was retrospectively reviewed. All patients received bevacizumab (10 mg/kg) and irinotecan (340 mg/m2 or 125 mg/m2) every two weeks. Patient clinical characteristics, drug toxicities, response rate, progression free survival (PFS) and overall survival (OS) were evaluated. Results. Between August 2008 and November 2011, 19 patients with recurrent malignant gliomas (median age 44.7, male 73.7%, WHO performance status 0%2) were treated with bevacizumab/irinotecan regimen. Thirteen patients had glioblastoma, 5 anaplastic astrocytoma and 1 anaplastic oligoastrocytoma. With exception of one patient, all patients had initially a standard therapy with primary resection followed by postoperative chemoradiotherapy. Radiological response was confirmed after 3 months in 9 patients (1 complete response, 8 partial responses), seven patients had stable disease and three patients have progressed. The median PFS was 6.8 months (95% confidence interval [CI]: 5.3-8.3) with six-month PFS rate 52.6%. The median OS was 7.7 months (95% CI: 6.6-8.7), while six-month and twelve-month survival rates were 68.4% and 31.6%, respectively. There were 16 cases of hematopoietic toxicity grade (G) 1-2. Non-hematopoietic toxicity was present in 14 cases, all G1-2, except for one patient with proteinuria G3. No grade 4 toxicities, no thromboembolic event and no intracranial hemorrhage were observed. Conclusions. In recurrent malignant gliomas combination of bevacizumab and irinotecan might be an active regimen with acceptable toxicity.
Ključne besede: recurrent malignant glioma, systemic therapy, bevacizumab
Objavljeno v DiRROS: 17.04.2024; Ogledov: 43; Prenosov: 5
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3. The core of a vertex-transitive complementary prismMarko Orel, 2023, izvirni znanstveni članek Povzetek: The complementary prism $\Gamma \overline{\Gamma}$ is obtained from the union of a graph $\Gamma$ and its complement $\overline{\Gamma}$ where each pair of identical vertices in $\Gamma$ and $\overline{\Gamma}$ is joined by an edge. It generalizes the Petersen graph, which is the complementary prism of the pentagon. The core of a vertex-transitive complementary prism is studied. In particular, it is shown that a vertex-transitive complementary prism $\Gamma \overline{\Gamma}$ is a core, i.e. all its endomorphisms are automorphisms, whenever $\Gamma$ is a core or its core is a complete graph.
Ključne besede: graph homomorphism, complementary prism, self-complementary graph, vertex-transitive graph, core
Objavljeno v DiRROS: 09.04.2024; Ogledov: 54; Prenosov: 25
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4. Sliding wear behaviour of conventional and cryotreated PM Cr-V (Vanadis 6) ledeburitic tool steelVenu Yarasu, Peter Jurči, Peter Gogola, Bojan Podgornik, Marko Sedlaček, 2023, izvirni znanstveni članek Ključne besede: cold work tool steel, conventional treatment, cryogenic treatment, hardness, reciprocal sliding, wear
Objavljeno v DiRROS: 08.04.2024; Ogledov: 67; Prenosov: 13
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6. Transcriptome-informed identification and characterization of Planococcus citri cis- and trans-isoprenyl diphosphate synthase genesMojca Juteršek, Iryna Gerasymenko, Marko Petek, Kristina Gruden, Špela Baebler, 2024, izvirni znanstveni članek Povzetek: Insect physiology and reproduction depend on several terpenoid compounds, whose biosynthesis is mainly unknown. One enigmatic group of insect monoterpenoids are mealybug sex pheromones, presumably resulting from the irregular coupling activity of unidentified isoprenyl diphosphate synthases (IDSs). Here, we performed a comprehensive search for IDS coding sequences of the pest mealybug Planococcus citri. We queried the available genomic and newly generated short- and long-read P. citri transcriptomic data and identified 18 putative IDS genes, whose phylogenetic analysis indicates several gene family expansion events. In vitro testing confirmed regular short-chain coupling activity with five gene products. With the candidate with highest IDS activity, we also detected low amounts of irregular coupling products, and determined amino acid residues important for chain-length preference and irregular coupling activity. This work therefore provides an important foundation for deciphering terpenoid biosynthesis in mealybugs, including the sex pheromone biosynthesis in P. citri.
Ključne besede: insect pheromones, isoprenyl diphosphate synthase, monoterpenes, phylogenetic analysis
Objavljeno v DiRROS: 29.03.2024; Ogledov: 77; Prenosov: 33
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7. Tumor size and effectiveness of electrochemotherapyBarbara Mali, Damijan Miklavčič, Luca Giovanni Campana, Maja Čemažar, Gregor Serša, Marko Snoj, Tomaž Jarm, 2013, izvirni znanstveni članek Ključne besede: electrochemotherapy, cutaneous tumors, effectiveness, tumor size, meta-analysis
Objavljeno v DiRROS: 22.03.2024; Ogledov: 76; Prenosov: 28
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8. Lower tumour burden and better overall survival in melanoma patients with regional lymph node metastases and negative preoperative ultrasoundGašper Pilko, Janez Žgajnar, Maja Marolt-Mušič, Marko Hočevar, 2012, izvirni znanstveni članek Povzetek: Background. The purpose of the study was to evaluate the ability of ultrasound(US) and fine needle aspiration biopsy (FNAB) in reducing the numberof melanoma patients requiring a sentinel node biopsy (SNB); to compare the amount of metastatic disease in regional lymph nodes in SNB candidates with clinically uninvolved lymph nodes and of those with US uninvolved lymph nodes; and to compare the overall survival (OS) of both groups. Methods. Between 2000 and 2007, a SNB was successfully performed in 707 patients with melanoma. The preoperative US of the regional lymph node basins was performed in 405 SNB candidates. In 14 of these patients, the US-guided FNAB was positive and they proceeded directly to lymph node dissection. In 391 patients, the preoperative US was either negative (343 patients) or suspicious(48 patients) (US group). In the remaining 316 patients the preoperative US was not performed (non-US group). Results. The proportion of macrometastatic sentinel lymph nodes (SN), number of metastatic lymph nodes per patient and proportion of nonsentinel lymph node metastases were found to be lower in the US group compared to the non-US group. The smaller tumour burden of the US group was reflected in a significantly better OS of patients with SN metastases. Conclusions. The preoperative US of regional lymph nodes spares some patients with melanoma from undergoing a SNB. Patients with regional metastases and a negative preoperative US have a significantly lower tumour burden in comparison to those with clinically negative lymph nodes, which is also reflected in a better OS.
Objavljeno v DiRROS: 22.03.2024; Ogledov: 67; Prenosov: 25
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10. Inguinal or inguino-iliac/obturator lymph node dissection after positive inguinal sentinel lymph node in patients with cutaneous melanomaNebojša Glumac, Marko Hočevar, Vesna Zadnik, Marko Snoj, 2012, izvirni znanstveni članek Povzetek: The aim of the study was to determine whether the presence of inguinal sentinel lymph node (SLN) metastases smaller than 2 mm (micrometastases) subdivided according to the number of micrometastases predicts additional, non-sentinel inguinal, iliac or obturator lymph node involvement in completion lymph node dissection (CLND). Positive inguinal SLN was detected in 58 patients (32 female, 26 male, median age 55 years) from 743 consecutive and prospectively enrolled patients with primary cutaneous melanoma stage I and II who were treated with SLN biopsy between 2001 and 2007. Micrometastases in inguinal SLN were detected in 32 patients, 14 were single, 2 were double, and 16 were multiple. Twenty-six patients had macrometastases. No patient with any micrometastases or a single SLN macrometastasis in the inguinal region had any iliac/obturator non-sentinel metastases after CLND in our series. Furthermore, no patient with single SLN micrometastasis in the inguinal region had any non-sentinel metastases at all after CLND in our series. In these cases respective CLND might be omitted.
Objavljeno v DiRROS: 21.03.2024; Ogledov: 54; Prenosov: 23
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