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12. PD-L1 expression can be regarded as prognostic factor for survival of non-small cell lung cancer patients after chemoradiotherapyMartina Vrankar, Matjaž Zwitter, Izidor Kern, Karmen Stanič, 2018, izvirni znanstveni članek Povzetek: The standard treatment for inoperable locally advanced non-small cell lung cancer (LA NSCLC) includes concurrent or sequential chemotherapy (ChT) and radiation therapy (RT). Long term survival rates with these approaches remains only in the order of 15%, therefore new treatment strategies, including immunotherapy, are under investigation, with programmed death ligand-1 (PD-L1) as one of the major players. We evaluated the clinical significance of PD-L1 expression in tumor samples from patients with inoperable LA NSCLC who underwent concurrent chemoradiotherapy (CRT) in our institution between 2005 and 2010 and correlated their expression with clinicopathological parameters and outcome of treatment. Among 107 patients treated with concurrent CRT, a total of 43 (36 males and 7 females) had sufficient tissue for immunohistochemical (IHC) staining. The expression of PD-L1 was demonstrated in 7 tumors, in 6 males and 1 female. No statistical significant differences in patient characteristics, including age, smoking status and gender, were found according to the PD-L1 expression. After a median follow up of 103.6 months, median progression free survival (PFS) was 19.9 months in patients without and 10.1 months in patients with PD-L1 expression (p=0.008). Median overall survival (OS) was 28.4 and 12.1 months for PD-L1 negative and PD-L1 positive patients, respectively (p=0.012). In conclusions, patients with PD-L1 expression had shorter PFS and OS after concurrent CRT in LA NSCLC. Unfortunately, only small number of patients had tissue available for the IHC testing, therefore no firm conclusions could be made and further investigation is warranted.
Ključne besede: non-small cell lung cancer, lung cancer, chemoradiotherapy, survival
Objavljeno v DiRROS: 17.12.2020; Ogledov: 1326; Prenosov: 418
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13. Stereotaktično obsevanje : novi izzivi zdravljenja v radioterapiji : [strokovno srečanje : elektronski zbornik prispevkov : v Ljubljani, 27.11. 2020]2020, strokovna monografija Povzetek: Stereotaktično obsevanje, tehnika obsevanja, s katero dovedemo visoko obsevalno dozo na manjšo tarčo kjerkoli v telesu, predstavlja eno izmed možnosti radikalnega zdravljenja nekaterih tumorjev, zasevkov ali celo benignih stanj. Stereotaktično obsevanje je neinvazivno, stroški zdravljenja so nizki, bolnikom omogoča hitrejšo vrnitev v domače oziroma delovno okolje, ne poslabša kvalitete življenja in ima nizko stopnjo akutne morbiditete in mortalitete. V skrbnih radioterapevtskih postopkih, od izbora primernih bolnikov za stereotaktično obsevanje, priprave na obsevanje in izdelave obsevalnega načrta, kontrole kvalitete obsevanja, izvedbe obsevanja na linearnem pospeševalniku ter bolnikove oskrbe, sodelujemo zdravniki onkologi radioterapevti, radiologi, medicinski fiziki, dozimetristi, radiološki inženirji, medicinske sestre in zdravstveni tehniki. Skupen cilj naše timske obravnave in naporov medicinskega osebja je predvsem izboljšanje rezultatov zdravljenja ter ohranitev oziroma izboljšanje kvalitete življenja vsakega posameznega bolnika. Veliko pozornosti posvečamu tudi zmanjševanju tveganja za pojav kratkoročnih ali dolgoročnih neželenih učinkov stereotaktičnega obsevanja.
Ključne besede: radioterapija, elektronske knjige
Objavljeno v DiRROS: 08.12.2020; Ogledov: 1977; Prenosov: 512
 Celotno besedilo (14,11 MB) |
14. Prognostic value of PD-L1 expression in patients with unresectable stage III non-small cell lung cancer treated with chemoradiotherapyMartina Vrankar, Izidor Kern, Karmen Stanič, 2020, izvirni znanstveni članek Povzetek: Background: Expression of PD-L1 is the most investigated predictor of benefit from immune checkpoint blockade in advanced NSCLC but little is known about the association of PD-L1 expression and clinicopathological parameters of patients with unresectable stage III NSCLC. Methods: National registry data was searched for medical records of consecutive inoperable stage III NSCLC patients treated with ChT and RT from January 2012 to December 2017. Totally 249 patients were identified that met inclusion criteria and of those 117 patients had sufficient tissue for PD-L1 immunohistochemical staining. Results: Eighty patients (68.4%) expressed PD-L1 of >- 1% and 29.9% of more than 50%. Median PFS was 15.9 months in PD-L1 negative patients and 16.1 months in patients with PD-L1 expression >- 1% (p = 0.696). Median OS in PD-L1 negative patients was 29.9 months compared to 28.5 months in patients with PD-L1 expression >- (p = 0.888). There was no difference in median OS in patients with high PD-L1 expression (>- 50%) with 29.8 months compared to 29.9 months in those with low (1-49%) or no PD-L1 expression (p = 0.694). We found that patients who received a total dose of 60 Gy or more had significantly better median OS (32 months vs. 17.5 months, p < 0.001) as well as patients with PS 0 (33.2 vs. 20.3 months, p = 0.005). Conclusions: In our patients PD-L1 expression had no prognostic value regarding PFS and OS. Patients with good performance status and those who received a total radiation dose of more than 60 Gy had significantly better mOS.
Ključne besede: non small cell lung cancer, chemoradiotherapy, stage III
Objavljeno v DiRROS: 09.11.2020; Ogledov: 1419; Prenosov: 1011
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15. Priporočila za obravnavo bolnikov s pljučnim rakomMartina Vrankar, Nina Boc, Izidor Kern, Aleš Rozman, Karmen Stanič, Tomaž Štupnik, Mojca Unk, Maja Ebert Moltara, Vesna Zadnik, Katja Adamič, Jernej Benedik, Marko Bitenc, Jasna But-Hadžić, Anton Crnjac, Eva Ćirić, Tanja Čufer, Goran Gačevski, Marta Globočnik Kukovica, Kristina Gornik-Kramberger, Maja Ivanetič Pantar, Staša Jelerčič, Veronika Kloboves-Prevodnik, Mile Kovačević, Luka Ležaič, Mateja Marc-Malovrh, Katja Mohorčič, Bogdan Vidmar, Dušanka Vidovič, Gregor Vlačić, Ana Lina Vodušek, Rok Zbačnik, Ivana Žagar, 2020, strokovni članek Ključne besede: pljučni rak, priporočila
Objavljeno v DiRROS: 22.09.2020; Ogledov: 1848; Prenosov: 688
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16. Vodnik za bolnike z nedrobnoceličnim pljučnim rakom v stadiju IIIMartina Vrankar, Karmen Stanič, 2019, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid Ključne besede: rak pljuč, nedrobnocelični pljučni rak, imunoterapija, zdravljenje, kemoradioterapija
Objavljeno v DiRROS: 28.05.2020; Ogledov: 1681; Prenosov: 553
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18. Zbornik2016, zbornik strokovnih ali nerecenziranih znanstvenih prispevkov na konferenci Ključne besede: diagnostika, urgentna stanja, kirurško zdravljenje, komplikacije, radioterapija, kemoterapija, tarčno zdravljenje, imunoterapija, napredovali rak, paliativna oskrba, podporno zdravljenje, alternativno zdravljenje, nedrobnocelični pljučni rak, rehabilitacija
Objavljeno v DiRROS: 15.05.2020; Ogledov: 1917; Prenosov: 596
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