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Query: "author" (Jože Pižem) .

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1.
Detection of apoptotic cells in tumour paraffin sections
Jože Pižem, Andrej Cör, 2003, professional article

Abstract: Apoptosis is a distinct form of cell death characterised by specific morphological features and regulated by complex molecular mechanisms. Its deregulation is fundamental for tumour growth and progression and, moreover, anticancer therapies suppress tumour growth mainly by induction of apoptosis. Since the extent of apoptosis in a tumour may have prognostic as well as therapeutic implications, much effort has been invested in developing specificmethods that can be routinely used to detect apoptotic cells in archival formalin fixed paraffin-embedded tissue. Complex molecular pathways are involved in the regulation of apoptosis. Pro-apoptotic signals trigger activation of caspases that specifically cleave target proteins. Cleavage of proteins (caspase substrates) is responsible for morphological changes of apoptotic cells and DNA fragmentation. In the last decade, detection of apoptotic cells in formalin fixed tumour tissue sections has been based mainlyon morphology and characteristic DNA fragmentation. Recently, specific antibodies to activated caspases and cleaved target proteins (including cytokeratin 18, actin and PARP) have been produced that enable accurate detection of apoptosis in paraffin sections.
Published in DiRROS: 06.02.2024; Views: 115; Downloads: 29
.pdf Full text (170,01 KB)

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Survivin - an inhibitor of apoptosis and a new therapeutic target in cancer
Jože Pižem, Andrej Cör, 2003, professional article

Abstract: Survivin is a unique member of the inhibitor of apoptosis (IAP) protein family. It inhibits apoptosis by interfering with post-mitochondrial events during apoptosis, thus blocking activation of caspases. The expression of survivin is among the most tumour specific of all human genes. It is overexpressed in most human cancers but is not detected in most normal tissues. Some molecular mechanisms of survivin upregulation in cancer have been elucidated, including loss of the wild-type p53. Tumours that overexpresssurvivin generally bear a worse prognosis and are associated with resistance to therapy. Its differential expression in caneer versus normal tissues makes survivin detection a useful tool in cancer diagnostics and a promising therapeutic target. Survivin targeting has resulted in increased spontaneous and induced apoptosis and inhibition of tumourgrowth. Some anticaneer drugs currently introduced into clinical practice might well act byinactivaring survivin.
Published in DiRROS: 06.02.2024; Views: 123; Downloads: 27
.pdf Full text (185,35 KB)

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Ploščatocelični rak kože : priporočila za zdravljenje
Barbara Perić, Olga Blatnik, Boštjan Luzar, Jože Pižem, Janja Ocvirk, Marko Hočevar, Primož Strojan, Tomi Bremec, Martina Reberšek, 2020, dictionary, encyclopaedia, lexicon, manual, atlas, map

Keywords: ploščatocelični rak, rak kože, bolniki, zdravljenje
Published in DiRROS: 17.03.2022; Views: 647; Downloads: 343
.pdf Full text (842,08 KB)
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Smernice & klinična pot za obravnavo bolnikov z melanomom
Primož Strojan, Uroš Ahčan, Marko Snoj, Boštjan Luzar, Jože Pižem, Boris Jančar, Martina Reberšek, Borut Žgavec, Tanja Planinšek Ručigaj, Aleksandra Dugovnik, 2010, dictionary, encyclopaedia, lexicon, manual, atlas, map

Keywords: klasifikacija, smernice, preživetje
Published in DiRROS: 28.08.2020; Views: 1595; Downloads: 681
.pdf Full text (11,72 MB)

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