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Abstract: Background. Intraspinal synovial cysts of vertebral facet joints are uncommon cause of radicular pain as well as neurological deficits. They can be managed both conservatively and surgically.Case report. A 77-year old polymorbid patient presented with bilateral low back pain which worsened during the course of time and did not respond to the conservative treatment. A diagnosis of intraspinal synovial cyst was made using the magnetic resonance imaging (MRI). Percutaneous computed tomography (CT) guided injection with installation of local anesthetic together with corticosteroid and rupture of the cyst was successfully used. A month after the procedure his pain improved, the usage of analgesics diminished and his over-all quality of life improved.Conclusions. Percutaneous CT guided lumbar synovial cyst treatment is safe and reliable alternative to the surgical treatment in polymorbid patients with radiculopathy who are not able to tolerate general anesthesia and operation.
Keywords: ciste, intraspinalne sinovialne ciste, bolečina, zdravljenje, radiologija
Published in DiRROS: 11.04.2024; Views: 60; Downloads: 31
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Abstract: A model organic pigment (diketopyrrolopyrrole) is encapsulated by a silica coating in order to improve its photochemical stability. Unlike in previous works where single-layer silica coatings were used for similar purposes, we here propose creation of a multi-layer silica shell synthesized via in-situ sol-gel method, which should significantly improve the homogeneity and thus the protection ability of the coating. This is done by repeating the basic two-step process (pigment surface modification and silica encapsulation) several times, creating the final protective shell in a layer-by-layer fashion. The compositional and structural properties of the prepared coatings is studied using Fourier-transform infrared spectroscopy, differential thermal and thermogravimetric analysis, nitrogen adsorption measurements and transmission electron microscopy. Photochemical stability of non-encapsulated and encapsulated pigment particles is evaluated via the so-called fast-irradiation method. Various correlations between the essential coating properties, such as thickness, porosity, SiO2 content, and the corresponding photochemical stability of the samples are established and discussed in detail. As a whole, our results confirm the basic hypothesis, that multiple-layered silica shells show improved pigment protection ability in comparison to the single-layer coatings.
Keywords: organic pigments, silica coating, encapsulation, morphology, photocemical stability
Published in DiRROS: 27.03.2024; Views: 87; Downloads: 43
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Abstract: Background. Electrochemotherapy is a local treatment combining application of electric pulses and chemotherapy. Two chemotherapeutic drugs, bleomycin and cisplatin, have proved to be effective in electrochemotherapy. The effectiveness of electrochemotherapy was demonstrated in the treatment of various cutaneous and subcutaneous tumours in cancer patients. Only a few preclinical studies were performed in colorectal carcinoma, mostly using bleomycin. Our aim was to evaluate the sensitivity of the murine colorectal carcinoma cell line CMT-93 to electrochemotherapy with bleomycin and cisplatinfor potential use in preclinical and clinical studies. Methods. CMT-93 cells were exposed to either the chemotherapeutic drug alone or electrochemotherapy. A clonogenic assay was used to determine cell survival after treatment. Apoptosis was measured by caspase-3/7 activity, necrosis by changes in cell morphology and cell viability by the MTS assay 16 hours after electrochemotherapy. Results. Cells treated with electrochemotherapy were 500-fold more sensitive to bleomycin and 2.8-fold more sensitive to cisplatin compared to cells treated with the drugs alone. At the highest concentrations,a significant reduction in cell viability, increase in caspase-3/7 activity and necrotic cells were observed after electrochemotherapy. Conclusions. Exposure of cells to electric pulses enhanced cytotoxicity of both bleomycin and cisplatin. Reduced cell viability was due to apoptotic and necrotic cell death. Furthermore, electrochemotherapywith bleomycin was more cytotoxic than electrochemotherapy with cisplatin in this colorectal carcinoma cell line.
Published in DiRROS: 18.03.2024; Views: 61; Downloads: 22
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Published in DiRROS: 26.02.2024; Views: 122; Downloads: 66
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Abstract: We study the existence of solutions of mixed Riemann-Hilbert or Cherepanov boundary value problem with simply connected fibers on the unit disk $\Delta$. Let ▫$L$▫ be a closed arc on $\partial\Delta$ with the end points $\omega_{-1}, \omega_1$ and let $a$ be a smooth function on $L$ with no zeros. Let $\{\gamma_{\xi}\}_{\xi\in\partial\Delta\setminus\mathring{L}}$ be a smooth family of smooth Jordan curves in $\mathbb C$ which all contain point $0$ in their interiors and such that $\gamma_{\omega_{-1}}$, $\gamma_{\omega_{1}}$ are strongly starshaped with respect to $0$. Then under condition that for each $w\in \gamma_{\omega_{\pm 1}}$ the angle between $w$ and the normal to $\gamma_{\omega_{\pm 1}}$ at $w$ is less than $\frac{\pi}{10}$, there exists a Hölder continuous function $f$ on $\overline{\Delta}$, holomorphic on $\Delta$, such that ${\rm Re}(\overline{a(\xi)} f(\xi)) = 0$ on $L$ and $f(\xi)\in\gamma_{\xi}$ on $\partial\Delta\setminus\mathring{L}$.
Keywords: boundary value problems, mixed Riemann-Hilbert problem, Cherepanov problem
Published in DiRROS: 15.02.2024; Views: 115; Downloads: 56
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