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Query: "author" (Metka Ravnik-Glavač) .

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1.
Genetic polymorphisms of xenobiotic metabolizing enzymes in human colorectal cancer
Vita Dolžan, Metka Ravnik-Glavač, Katja Breskvar, 1998, published scientific conference contribution

Abstract: It was proposed that both hereaditary and environmental factors contribute to the development of colorectal cancer (CRC). Carcinogenic polycyclic aromatic hydrocarbons (PAHs) from food or tobacco smoke can form DNA adducts and thus initiate carcinogenesis after metabolic activation via cytochrome P4501A1 (CYP1A1). Intermediate metabolites are detoxified by conjugation with glutathione S-transferases. Our aim was to look for inherited metabolic suceptibility to CRC. We used PCR-based genotyping approach to determine the frequencies of polymorphic alleles of two cytochromes P450 (CYP2D6 and CYP1A1)and two glutathione S-transferases (GSTM1 and GSTT1) in DNA samples from 31 sporadic, 25 familial CRC cases and 73 healthy controls. The difference in frequencies of poor metabolisers due to CYP2D6 gene polymorphismwas close to the limit of statistical significance between sporadiCRC and healthy control group (lambda 2=5.52, m=2, p=0.06) despite the small sample size. The frequencies of either CYP1A1 MspI, GST M1 or GST T1 genotypes were not significantly different in both CRC cases and in controls. Although our study suggests some difference in metabolic susceptibility between sporadic and familial CRC, further studies are needed to investigate the combined effect of polymorphic genes involved in carcinogen metabolism in a larger group of patients with defined exposure to dietary carcinogens and smoking.
Published in DiRROS: 19.01.2024; Views: 150; Downloads: 37
.pdf Full text (1,37 MB)

2.
Molekularna genetika dednega raka
Metka Ravnik-Glavač, Damjan Glavač, 2000, published scientific conference contribution

Published in DiRROS: 17.09.2019; Views: 2597; Downloads: 453
.pdf Full text (422,93 KB)

3.
Molekularna genetika pljučnega raka
Damjan Glavač, Metka Ravnik-Glavač, 1998, published scientific conference contribution

Published in DiRROS: 16.09.2019; Views: 2292; Downloads: 458
.pdf Full text (330,07 KB)

4.
Mikrosatelitna nestabilnost pri kolorektalnih karcinomih
Metka Ravnik-Glavač, 2006, published professional conference contribution

Keywords: mikrosatelitna nestabilnost, kolorektalni karcinomi, genetika
Published in DiRROS: 16.09.2019; Views: 1738; Downloads: 492
.pdf Full text (235,77 KB)

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