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Query: "author" (Marija Us-Krašovec) .

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91.
Imunoterapija in obsevanje pri primarnih in sekundarnih možganskih tumorjih
Marija Skoblar Vidmar, 2021, published professional conference contribution

Keywords: imunoterapija, radioterapija, onkološko zdravljenje
Published in DiRROS: 30.03.2022; Views: 447; Downloads: 229
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92.
Staroselske kozmologije v okviru novih epistemoloških in političnih teženj globalnega Juga
Marija Mojca Terčelj, 2021, original scientific article

Abstract: Bistvena razlika med staroselskimi verstvi in svetovnimi religijami je v pojmovanju odnosa »človek – narava«. Staroselska verstva dojemajo človeka kot enakovrednega akterja pri vzpostavljanju kozmične harmonije, torej ga postavljajo ob bok vsem drugim živim in neživim bitjem stvarstva, medtem ko ga svetovne religije umeščajo v središče sveta. Krščansko religiozno izročilo na eni strani ter kartezijanski ontološki dualizem in metodološki empirizem na drugi so močno vplivali na razvoj zahodnjaške znanstvene misli. Družbene in humanistične vede so v zadnjih desetletjih naredile velik korak – prispevale so k novim razlagam glo-balnih ekonomskih in socialnih zakonitosti ter hibridizacije etničnih identitet in začele tesneje sodelovati z empiričnimi znanostmi. Problem nastane, ko je zaradi lastne zazrtosti katera koli druga vrsta znanja diskvalificirana kot »neznanstvena«, »lokalna«, »romantična«, nepopolna. V začetku 21. stoletja je staroselska kozmologija vstopila v politični diskurz in ideologijo številnih socialnih gibanj globalnega Juga. Na podlagi primerjalne analize treh konkretnih staroselskih kozmoloških in religioznih modelov (odnos človek – narava) želi članek opozoriti na potrebo po pluralizmu miselnih konceptov in družbenih praks.
Keywords: človek - narava, staroselci, pačamamizem, ekologija, razvoj
Published in DiRROS: 22.03.2022; Views: 577; Downloads: 363
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93.
Priporočila za obravnavo bolnikov z rakom debelega črevesa in danke
2020, dictionary, encyclopaedia, lexicon, manual, atlas, map

Keywords: rak debelega črevesa, rak danke, bolniki, zdravljenje
Published in DiRROS: 18.03.2022; Views: 781; Downloads: 421
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Podobe gozdnega revirja
Anton Lesnik, Gal Fidej, Jože Prah, Jože Mori, Jože Kos, Jurij Diaci, Kristina Sever, Marija Imperl, 2022, popular article

Keywords: revirni gozdar
Published in DiRROS: 08.03.2022; Views: 832; Downloads: 201
.pdf Full text (522,26 KB)

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Next-generation sequencing to characterize pyrazinamide resistance in Mycobacterium tuberculosis isolates from two Balkan countries
Eva Sodja, Simon Koren, Nataša Toplak, Sara Truden, Marija Žolnir-Dovč, 2021, original scientific article

Abstract: Objectives. Next-generation sequencing (NGS) provide a comprehensive analysis of the genetic alterations that are most commonly linked with pyrazinamide (PZA) resistance. There are no studies reporting molecular background of PZA resistance in TB isolates from Balkan Peninsula. We aimed to examine the feasibility of full-length analysis of a gene linked with PZA resistance, pncA, using Ion Torrent technology in comparison to phenotypic BACTEC MGIT 960 DST in clinical TB isolates from two countries of the Balkan Peninsula. Methods. Between 1996 and 2017, we retrospectively selected 61 TB isolates. To identify gene variants related to drug resistance in genomic DNA extracted from TB isolates, AmpliSeq libraries were generated automatically using the AmpliSeq™ Kit for Chef DL8 and the Ion AmpliSeq TB Research Panel. Result.s Of all 61 TB isolates included, 56 TB were phenotypically resistant to any antibiotic. Among them, 38/56 (67.9%) TB isolates were phenotypically resistant to pyrazinamide and pncA mutations were detected in 33/38 cases (86.8%). A mutation in the pncA promoter region was the most prevalent genetic alteration, detected in eight TB isolates. Comparison of NGS to conventional BACTEC MGIT 960 DST revealed very strong agreement (90.2%) between the two methods in identifying PZA resistance, with high sensitivity (89.5%) and specificity (95.7%) for NGS. Conclusions. Detection of PZA resistance using NGS seems to be a valuable tool for surveillance of TB drug resistance also in the Balkan Peninsula, with great potential to provide useful information at least one weak earlier than is possible with phenotypic DST.
Keywords: tuberculosis, Mycobacterium tuberculosis, high-throughput nucleotide sequencing, pyrazinamide, microbial sensitivity tests, next-generation sequencing, drug susceptibility testing, Slovenia, Republic of North Macedonia
Published in DiRROS: 10.01.2022; Views: 856; Downloads: 524
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