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Query: "author" (Janez %C5%BDgajnar) .

31 - 40 / 497
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31.
Transjugular intrahepatic portosystemic shunt (TIPS)
Miloš Šurlan, Janez Jereb, 2000, review article

Abstract: Background. A clear presentation of TIPS indications and contraindications, which can be divided into absolute and relative, is given. Absolute indications are fresh and renewed bleeding of varices and inveterate ascites. Relative indications, on the other hand, are splenomegaly with hypersplenism, Budd-Chiari syndrome, liver transplantation and hepatorenal syndrome. Absolutecontraindications are severe liver dysfunction and right heart failure, while the relative ones polycystic liver degeneration, neoplasm, obstruction of the portal vein and severe local and systemic infection. Beforethe TIPS procedure, the level of dysfunction of the liver, right heart and kidneys is determined. Biochemical and blood tests, including a blood coagulation test, are made, the ammonia level in the serum is determined and possible obstructions/strictures of the portal vein are checked. A detailed description of the procedure, a care for patient and a operative monitoring are given. The success rate of the procedure is between 93% and 100% and the mortality rate within 30 days because TIPS is between 1% and 3%. The hemorrhage is stopped in 95% to 100%, the ascites is improved in 87% to 92% and the kidney function in 81%. In case of hypersplenism the thrombocytopenia is improved in 75% and leucopenia in 50% of patients. There are relatively fewcomplications during the procedure. Postoperative complications are more frequent due to stricture and obstruction of the shunt. After a two-year treatment the shunt is passable in 50% of patients. Thus, in a group of 29 patients, who were treated in the period of four years with an average monitoring period of two years, 22 patients (75,9%) are still alive and only 7died (24,1%). Six of dead patients suffered from alcoholic cirrhosis of the liver. In two cases the cause of death was not related to the TIPS and the cirrhosis of the liver. (Abstract truncated at 2000 characters).
Published in DiRROS: 23.01.2024; Views: 127; Downloads: 35
.pdf Full text (523,61 KB)

32.
Cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and alignant ovarian tissues : a preliminary report
Marina Šprem, Damir Babić, Marija Abramić, Duško Miličić, Ivan Vrhovec, Janez Škrk, Maja Osmak, 2000, original scientific article

Abstract: Background. The aim of the present study was to determine the concentration ofcathepsin D (Cath D) and plasminogen activator inhibitor type 1 (PAI-1) in normal ovarian tissues, benign and malignant ovarian tumor tissues, and to asses relationship between Cath D and PAI-1 content, and some clinical and pathohistological parameters. Materials and methods. Cath D contents and PAI-1concentrations were determined (using immunoradiometric ELSA-Cath D assayand commercial IMUDIND R ELISA immunoassay, respectively) in 35 samples: 10 normal ovarii, 10 benign, 10 primary malignant and 5 metastatic ovarian tumors. Results. The concentrations of Cath D were significantly higher in malignant (32.89+-14.26 pmol/mg protein ) and metastatic (31.42+-10.24 pmol/mgprotein), than in normal (13.68+-4.03 pmol/mg protein) and benign (17.89+-13.13 pmol/mg protein) ovarian tissues. There was no statistical differences in the concentrations of PAI-1 between normal, benign, malignant and metastatic tumor specimens. The concentrations of Cath D as well as PAI-1 did not correlate to the age of patients, menopausal status, parity, GOG risk group, clinical stage or pathohistological grading. Conclusion. Concentrationsof Cath D (but not PAI-1) were significantly increased in malignant and metastatic ovarian tumor tissues when compared to normal and benign ovarian tumor samples; they were independent from pathohistological andclinical parameters.
Published in DiRROS: 23.01.2024; Views: 131; Downloads: 51
.pdf Full text (442,49 KB)

33.
Cathepsin H in squamous cell carcinoma of the head and neck
Primož Strojan, Marjan Budihna, Alojz Šmid, Branka Svetic, Ivan Vrhovec, Janko Kos, Janez Škrk, 1999, original scientific article

Published in DiRROS: 22.01.2024; Views: 134; Downloads: 36
.pdf Full text (557,02 KB)

34.
Three-layer template for low-dose-rate remote afterload transperineal interstitial brachytherapy
Janez Kuhelj, Primož Strojan, Janez Burger, 1997, original scientific article

Published in DiRROS: 17.01.2024; Views: 157; Downloads: 39
.pdf Full text (131,28 KB)

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Local excision of flat adenomas of the rectum in the period from 1987 to 1991
Janez Novak, 1997, original scientific article

Abstract: In a period of 5 years, 35 patients underwent operations on for flat adenomas of the rectum located at a depth of 10 cm from the anocutaneous line. All the tumours were removed by transanal submucous excision. The average period of follow-up was 22 months. Three recurrences were detected and treated with reoperation. No major complications occurred. We consider our method suitable for clinical use if combined with careful follow-up.
Published in DiRROS: 16.01.2024; Views: 172; Downloads: 0

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Seventh international symposium on neutron capture therapy for cancer
Gregor Serša, Janez Škrk, 1996, other component parts

Published in DiRROS: 16.01.2024; Views: 154; Downloads: 32
.pdf Full text (108,08 KB)

40.
Prognostic value of staging laparotomy in supradiaphragmatic clinical stage I and II Hodgkin's disease
Marjeta Vovk, Tatjana Šumi-Križnik, Marija Jenko-Fidler, Gabrijela Petrič-Grabnar, Marinka Kremžar, Janez Novak, Mojca Senčar, Branko Zakotnik, Alenka Vodnik-Cerar, Branimir Jakšić, 1996, original scientific article

Abstract: In the period 1974-1989, 219 patients with supradiaphragmatic clinical stage I and II Hodgkin's disease were treated at the Institute of Oncology in Ljubljana; of these 95 (43%) patients underwent staging laparotomy. Of laparotomized patients, those with pathological stage III-IV, and of non-laparotomized, those with unfavorable prognostic factors (B-symptoms, bulky mediastinum) received chemotherapy: the remaining patients were treated by irradiation. No statistically significant difference in the survival and disease-free survival between laparotomized and nonlaparotomized patients could be found.
Published in DiRROS: 16.01.2024; Views: 148; Downloads: 42
.pdf Full text (364,35 KB)

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