1. Microinvasive cervical squamous cell carcinoma in Slovenia during the period 2001-2007Helena Gutnik, Jasenka P. Matišić, Maja Primic-Žakelj, Margareta Strojan Fležar, 2014, original scientific article Abstract: Background. Microinvasive squamous cell carcinoma (MISCC) comprises a significant portion of all cervical cancers in Slovenia. Criteria of carcinomatous invasion are well described in the literature, however histopathological assessment of MISCC is difficult, because morphological characteristics can overlap with cervical intraepithelial neoplasia grade 3 (CIN 3) and other pathological changes. The aim of our study was to evaluate the reliability of the histopathological diagnosis of MISCC in Slovenia during the period from 2001 to 2007. Materials and methods. Data on patients with a histopathological diagnosis of cervical MISCC (FIGO stage IA) in the period of 2001 to 2007 were obtained from the Cancer Registry of Slovenia. Histological slides were obtained from the majority of pathology laboratories in Slovenia. We received 250 cases (69% of all MISCC) for the review; 30 control cases with CIN 3 and invasive squamous cell carcinoma FIGO stage IB were intermixed. The slides were coded and reviewed. Results. Among 250 cases originally diagnosed as MISCC, there was an agreement with MISCC diagnosis in 184 (73.6%) cases (of these 179/184 (97.3%) cases were FIGO stage IA1 and 5/184 (2.7%) cases were FIGO stage IA2). Among 179 FIGO stage IA1 cases 117 (65.4%) showed only early stromal invasion. Conclusions. The retrospective review of cases diagnosed as MISCC during the period 2001- 2007 in Slovenia showed a considerable number of overdiagnosed cases. Amongst cases with MISCC confirmed on review, there was a significant proportion with early stromal invasion (depth of invasion less than 1 mm).
Keywords: cervical cancer, cervical squamous cell carcinoma, microinvasive squamous cell carcinoma, intraepithelial neoplasia
Published in DiRROS: 11.04.2024; Views: 86; Downloads: 19
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2. Smernice diagnostike in zdravljenja diferenciranega raka ščitniceNikola Bešić, Andreja A. Schwarzbartl-Pevec, Andreja Klevišar Ivančič, Barbara Vidergar-Kralj, Barbara Gazić, Blaž Krhin, Branko Zakotnik, Cvetka Grašič-Kuhar, Damijan Bergant, Edvard Pirnat, Helena Gutnik, Ivana Žagar, Jerca Blazina, Katja Zaletel, Margareta Strojan Fležar, Marko Hočevar, Marta Dremelj, Nebojša Glumac, Olga Blatnik, Simona Gaberšček, Snežana Pavlović Djokić, Ulrika Klopčič, Veronika Kloboves-Prevodnik, Živa Pohar-Marinšek, 2017, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: rak ščitnice, diferencirani rak, zdravljenje, smernice
Published in DiRROS: 27.05.2020; Views: 1900; Downloads: 617
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4. Potek zdravljenja bolnice s patološkim brisom in negativnim testom HPVTatjana Kodrič, Kristina Gornik-Kramberger, Simona Hutter-Čelik, Helena Gutnik, Rajko Kavalar, Alenka Repše-Fokter, 2013, published professional conference contribution Abstract: Presejalni program zgodnjega odkrivanja materničnega vratu temelji v Sloveniji na citološkem pregledu brisov materničnega vratu. V primeru patološkega citološkega izvida je potrebno opraviti tudi dodatne diagnostične preiskave in načrtovati ustrezno zdravljenje. Čeprav je velika večina predrakavih in rakavih bolezenskih sprememb na materničnem vratu pogojena s HPV-okužbo, pa se je potrebno zavedati, da obstoja možnost bolezni redko tudi pri populaciji z negativnim izvidom testa HPV.
Keywords: maternični vrat, novotvorbe, brisi, humani papiloma virus, prikaz primera
Published in DiRROS: 07.04.2020; Views: 1975; Downloads: 572
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