1. Mesenteric ischemia after capecitabine treatment in rectal cancer and resultant short bowel syndrome is not an absolute contraindication for radical oncological treatmentAna Perpar, Erik Brecelj, Nada Rotovnik-Kozjek, Franc Anderluh, Irena Oblak, Marija Skoblar Vidmar, Vaneja Velenik, 2015, short scientific article Abstract: Thrombotic events, arterial or venous in origin, still remain a source of substantial morbidity and mortality in cancer patients. The propensity for their development in oncology patients is partially a consequence of the disease itself and partially a result of our attempts to treat it. One of the rarest and deadliest thromboembolic complications is arterial mesenteric ischemia. The high mortality rate is caused by its rarity and by its non-specific clinical presentation, both of which make early diagnosis and treatment difficult. Hence, most diagnoses and treatments occur late in the course of the disease. The issue survivors of arterial mesenteric ischemia may face is short bowel syndrome, which has become a chronic condition after the introduction of parenteral nutrition at home. We present a 73-year-old rectal cancer patient who developed acute arterial mesenteric thrombosis at the beginning of the pre-operative radiochemotherapy. Almost the entire length of his small intestine, except for the proximal 50 cm of it, and the ascending colon had to be resected. After multiorgan failure his condition improved, and he was able to successfully complete radical treatment (preoperative radiotherapy and surgery) for the rectal carcinoma, despite developing short bowel syndrome (SBS) and being dependent upon home-based parenteral nutrition to fully cover his nutritional needs. Mesenteric ischemia and resultant short bowel syndrome are not absolute contraindications for radical oncological treatment since such patients can still achieve long-term remission.
Keywords: acute mesenteric ischemia, capecitabine, multiorgan failure, rectal cancer, short bowel syndrome
Published in DiRROS: 23.04.2024; Views: 4; Downloads: 2
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2. Phase II study of fluorouracil, leucovorin and interferon alpha-2a in patients with advanced colon cancerBorut Štabuc, Aleksandra Markovič, Erik Brecelj, Samir Bešlija, Tomaž-Edvard Cizej, 1998, original scientific article Abstract: Based on in viro studies that have demonstrated synergy between fluorouracil (5-FU) and leucovorin (LV) as well as between 5-FU and recombinant alpha-2a interferon (IFN) against colon cancer cell lines a phase II study was carried out to evaluate the toxicity and clinical activity of 5-FU modulated with LV and IFN in patients with metastatic colon cancer. Twenty-two chemotherapy naive patients with measurable metastases of colon cancer have been treated with daily doses of 5-FU 600 mg/m2 in 6-hr intravenous infusion, and of LV 20 mg/m2 intravenously and IFN 6 MU subcutaneously, for 5 days every 4 weeks. Median age was 60 years, median PS (ECOG) was 1 (range 0-2). Liver, soft tissue and lung metastases were found in 12, 5 and 8 patients, respectively. Nineteen patients had a single metastatic site, two double, whereas one had more than two metastatic sites. Patients had 2-9 (mean 5) cycles of treatment.Objective response was observed in 7 patients (32%), and stable disease in 7 patients (32%). Overall median survival was 12.5 months, and for responders 14.4 months. Responses were generally short and median time for progression was 5.5 months. The most frequent adverse reactions were flu-like syndrome (50%), nausea/vomiting (36%), diarhoea (13Č), stomatitis (27%) and leucopenia (13%). This regimen of 5-FU with LV and IFN administration does notappear to be superior to previously published shedules of 5-FU with IFN or 5-FU with LV.
Published in DiRROS: 19.01.2024; Views: 147; Downloads: 41
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3. Sodobno zdravljenje lokalno napredovalega in recidivnega raka dankeErik Brecelj, 2022, published scientific conference contribution Abstract: Zdravljenje lokalno napredovalega in recidivnega raka danke je zahtevno. Z uvedbo boljše diagnostike, novih načinov predoperativnega zdravljenja na eni strani in z bolj agresivno kirurško terapijo na drugi strani dosegamo več R0 resekcij, ki edine omogočajo potencialno ozdravitev. Še vedno pa so ti posegi za bolnike neredko mutilantni. Z ustreznimi tehnikami rekonstrukcije dosegamo večjo možnost resektabilnosti, hkrati pa so posledice kirurškega zdravljenja manjše. Pomembna pri vrnitvi bolnika v normalno življenje sta prehranska podpora in rehabilitacija. Tako kompleksno zdravljenje je možno samo v multidisciplinarnem timu.
Keywords: rak danke, kirurško zdravljenje, rak prebavil
Published in DiRROS: 13.01.2023; Views: 569; Downloads: 101
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4. Smernice za obravnavo bolnikov s skvamoznoceličnim karcinomom analnega kanala in kože perinealno (analnega roba)Franc Anderluh, Irena Oblak, Ajra Šečerov Ermenc, Ana Jeromen, Erik Brecelj, Martina Reberšek, Vaneja Velenik, 2022, professional article Keywords: rak analnega kanala, rak analnega roba, radiokemoterapija, obsevanje
Published in DiRROS: 15.12.2022; Views: 500; Downloads: 110
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5. Smernice za zdravljenje bolnikov z rakom požiralnika in ezofagogastričnega stika (EGS)Franc Anderluh, Marko Boc, Goran Gačevski, Gorana Gašljević, Samo Horvat, Nežka Hribernik, Marija Ignjatović, Ana Jeromen, Jera Jeruc, Peter Korošec, Tanja Mesti, Srdjan Novaković, Irena Oblak, Janja Ocvirk, Martina Reberšek, Nada Rotovnik-Kozjek, Matevž Srpčič, Ajra Šečerov Ermenc, Borut Štabuc, Vaneja Velenik, Neva Volk, Vesna Zadnik, 2022, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: rak požiralnika, rak ezofagogastritičnega stika, smernice, zdravljenje
Published in DiRROS: 07.09.2022; Views: 681; Downloads: 263
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6. Priročnik za bolnike z izločalno stomoAndreja Klinc, Dragica Tomc, Sabina Medjedović, 2021, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: rak črevesja, rak sečil, stoma
Published in DiRROS: 14.07.2022; Views: 611; Downloads: 188
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7. Smernice za obravnavo bolnikov s skvamoznoceličnim karcinomom analnega kanala in kože perinealno (analnega roba)2020, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: rak analnega kanala, rak analnega roba, bolniki, zdravljenje
Published in DiRROS: 18.03.2022; Views: 677; Downloads: 370
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8. Priporočila za obravnavo bolnikov z rakom debelega črevesa in danke2020, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: rak debelega črevesa, rak danke, bolniki, zdravljenje
Published in DiRROS: 18.03.2022; Views: 789; Downloads: 432
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9. Priporočila za obravnavo bolnikov z adenokarcinomom tankega črevesa2021, not set Keywords: rak (medicina), epidemiologija, preventiva, dedna predispozicija, diagnostika, kirurško zdravljenje, adjuvantna terapija, sistemsko zdravljenje, radioterapija, sledenje pacientov, medicinska rehabilitacija, paliativna oskrba, elektronske knjige
Published in DiRROS: 17.03.2022; Views: 687; Downloads: 345
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10. Priporočila Onkološkega inštituta za obravnavo bolnikov z adenokarcinomom tankega črevesaErik Brecelj, Vesna Zadnik, Ksenija Strojnik, Nina Boc, Gorana Gašljević, Jera Jeruc, Gašper Pilko, Martina Reberšek, Franc Anderluh, 2021, professional article Keywords: adenokarcinom tankega črevesa, priporočila, prebavni trakt, redki raki
Published in DiRROS: 16.12.2021; Views: 1032; Downloads: 438
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