Smernice za obravnavo bolnikov s skvamoznoceličnim karcinomom analnega kanala in kože perinealno (analnega roba)
Cancer of the anal canal and anal margin is a rare disease. In Slovenia, on average 20 patients are diagnosed with this disease each year, more women than men. However, the incidence has increased in the last year, mainly in young, homosexual men, most probably due to infections with the sexually-transmitted human papillomavirus (HPV) and human immunodeficiency virus (HIV), which are known causal agents of this disease. Cancer of the anal canal and anal margin is primarily a locoregional disease, as distant metastases are found in less than 10% of the patients. Radical radiochemotherapy plays the central role in the treatment of anal canal and anal margin carcinomas with no distant metastases, except in well-differentiated anal margin carcinomas smaller than 2 cm, where local excision is advised. Radical radiochemotherapy provides a complete response in as many as 80-90%, which is reflected also in an excellent treatment outcome with 5-year survival of 80%. Patients clinically staged as cT1-2 stand a 6.5% chance of developing inguinal lymph node metastases, while the likelihood in patients staged as cT3-4 is 16%. Surgery, namely abdominoperineal excision, has a role in the treatment of residual disease after radical radiochemotherapy. In the future, HPV vaccines hold great promise for the prevention of this virus-induced disease.
by Authors
2013
2018-08-31 13:31:00
1060
rak (medicina), debelo črevo, danka
Irena
Oblak
70
Vaneja
Velenik
70
Franc
Anderluh
70
Marija
Skoblar Vidmar
70
Jasna
But-Hadžić
70
Erik
Brecelj
70
Martina
Reberšek
70
Franc
Jelenc
70
Stojan
Potrč
70
UDK
4
616.35-006.6-08
ISSN pri članku
9
1408-1741
URN
14
URN:NBN:SI:doc-OE0IKK8M
COBISS_ID
3
1651323
OceCobissID
13
65324032
RAZ_Oblak_Irena_i2013.pdf
317189
Predstavitvena datoteka
2018-08-31 13:31:00