20.500.12556/DiRROS-8779
Vpliv pooperativne radioterapije pri multimodalnem zdravljenju lokalnmo napredovalega raka dojke
The impact of radiotherapy in multimodal management of locally advanced breast cancer
We retrospectively analyzed the data from 55 patients treated for noninflammatory locally advanced breast cancer (LABC) with neoadjuvant chemotherapy and surgery with or without radiotherapy. The mean follow-up was 55 months. The purpose was to evaluate and compare the impact of postoperative radiotherapy, whether it was indicated on the basis of clinical stage at presentation of the disease or on downstaged pathological disease after initial chemotherapy. The 3-year overall survival (OS) was 74%, disease-free survival (DFS) 73% and relapse-free survival (RFS) 87%. The OS and DFS benefit was seen in those receiving radiation, with a mean OS of 89 months vs. 68 months (p=0.029) and mean DFS of 72 months vs. 54 months (p=0.029). Total LRR was 11% (8% vs. 17% in no RT group, p=0,349) and mean RFS of 95 months vs. 86 months (p=0.164). Significantly lower OS and DFS of the patients who were not treated with radiotherapy suggest that the indication for radiation treatment should be based on clinical pre-chemotherapy stage rather than pathological post-chemotherapy stage for non-inflammatory LABC.
true
false
true
Slovenski jezik
Ni določen
by Authors
Neznano
2018-08-31 13:30:11
2018-08-31 13:30:11
2022-08-24 17:29:46
0000-00-00 00:00:00
2008
0
0
BSDOCID143368;
str. 89-93
št. 2
Letn. 12
2008
0000-00-00
Zaloznikova
Objavljeno
NiDoloceno
0000-00-00
0000-00-00
0000-00-00
616-006
1408-1741
URN:NBN:SI:doc-FHL0FV8M
25344473
65324032
RAZ_But_Hadzic_Jasna_i2008.pdf
RAZ_But_Hadzic_Jasna_i2008.pdf
1
10BB7E024537557199A5E794B51B9051
d3f8d3173fd4f89f65c4f95272e2542857539e0b1cbe393cdd1988b52c12090d
5d89e4eb-17b5-11ed-b6b8-001a4af901a5
20.500.12556/dirros/740201f0-987a-4138-b61f-d33b753a2ca2
https://dirros.openscience.si/Dokument.php?lang=slv&id=10560
Onkološki inštitut Ljubljana
Onkologija : strokovni časopis za zdravnike
0
0
0