Clinical significance of histologic subtyping of malignant pleural mesothelioma
Malignant mesothelioma (MM) is uncommon, but very aggressive tumor arising from the mesothelial cells of pleura, pericardium, peritoneum, and tunica vaginalis. Despite multimodality treatments 5-year survival is only 5% after the diagnosis. Histology and TNM staging system are still the best prognostic factors. Furthermore, histologic subtype of MM determines the clinical management of the patients. According to the 2015 WHO classification, MM is divided into diffuse, localized and well differentiated papillary mesothelioma. Major histologic subtypes of diffuse MM, namely epithelioid, biphasic and sarcomatoid, have different prognosis. However, in the last decade it has become evident that more detailed subclassification and histologic/cytological characterization of MM have prognostic and perhaps predictive implications. In this review, major histologic subtypes and cytological features of MM are presented and their relation with prognosis and predictive biomarkers is discussed.
Translational lung cancer research
2020
2020-06-22 12:48:20
1033
malignant mesothelioma, epithelioid malignant mesothelioma, biphasic malignant mesothelioma, sarcomatoid malignant mesothelioma
maligni mezoteliom, epiteloidni maligni mezoteliom, bifazni maligni mezoteliom, sarkomatoidni maligni mezoteliom
AME Publishing Company
Luka
Brčić
70
Izidor
Kern
70
UDK
4
616-006
ISSN pri članku
9
2226-4477
DOI
15
10.21037/tlcr.2020.03.38
COBISS_ID
3
17124867
OceCobissID
13
17120003
RAZ_Brcic_Luka_i2020.pdf
1953665
Predstavitvena datoteka
2021-05-14 14:56:04
0
Izvorni URL
2020-06-22 12:48:23